Gamma-glutamyl transferase (GGT) is an enzyme present in serum and on most cell surfaces and serves as an oxidative stress marker. Although serum GGT is associated with hypertension development, little data are available on the associations between GGT and hypertension among populations with diabetes mellitus (DM). Our aim was to investigate the potential association between the changes in syst...

A meta-analysis of 10 prospective cohort studies,1 including our own,2 reported that serum -glutamyltransferase (GGT) predicted incident vascular events. This metaanalysis posed one important, but unsolved question: why does serum GGT predict incident vascular events? In addition to vascular events, serum GGT predicts various important clinical outcomes including type 2 diabetes, metabolic synd...

background: considering that serum gamma-glutamyl transferase (ggt) activity could reflect several different processes relevant to diabetes pathogenesis and the increasing rate of type 2 diabetes worldwide, the aim of this study was to assess the association between serum ggt concentrations and glucose intolerance, in the first-degree relatives (fdr) of type 2 diabetic patients. methods: in thi...

BACKGROUND Serum Gamma-Glutamyl Transferase (GGT), a marker of oxidative stress, has been suggested to be independently associated with cardiovascular disease (CVD) events. We examined the association of serum GGT levels with the burden of subclinical inflammation across a spectrum of metabolic conditions. METHODS We evaluated 5,446 asymptomatic subjects (43 ± 10 years, 78 % males) who had an...

To the Editor: Krijgsman, Hamilton, and Mikhailidis make several points about possible mediators of the connection between serum -glutamyltransferase (GGT) activity and risk of cardiovascular disease. The authors first suggest that serum GGT may in part come from platelets and that because platelet breakdown may be increased at the sites of atheromatous plaques, people with substantial atherosc...

BACKGROUND Cholestatic liver diseases exhibit higher levels of serum γ-glutamyl transpeptidase (GGT) and incidence of secondary osteoporosis. GGT has been identified as a novel bone-resorbing factor that stimulates osteoclast formation. The aim of this study was to elucidate the interaction of elevated GGT levels and cholestatic liver disease-induced bone loss. METHODS Wistar rats were divide...

BACKGROUND Patients with idiopathic dilated cardiomyopathy (IDC) have impaired coronary flow reserve (CFR) and reduced CFR has been reported to be a poor prognostic indicator and independent predictor of subsequent cardiac events in patients with IDC. Serum gamma-glutamyltransferase (GGT) level is an independent risk factor for cardiovascular disease. Therefore, we aimed to determine whether se...

BACKGROUND Considering that serum gamma-glutamyl transferase (GGT) activity could reflect several different processes relevant to diabetes pathogenesis and the increasing rate of type 2 diabetes worldwide, the aim of this study was to assess the association between serum GGT concentrations and glucose intolerance, in the first-degree relatives (FDR) of type 2 diabetic patients. METHODS In thi...

BACKGROUND Our previous studies suggest that serum gamma-glutamyltransferase (GGT) activity may be related to oxidative stress, supporting findings of experimental studies. To further examine the role of GGT in relation to oxidative stress, we investigated the association between serum carotenoids and tocopherols, which have antioxidant properties, and serum GGT. METHODS Study participants we...

BACKGROUND Blood levels of gamma-glutamyl transferase (GGT) are used as a marker for (heavy) alcohol use. The role of GGT in the anti-oxidant defense mechanism that is part of normal metabolism supposes a causal effect of alcohol intake on GGT. However, there is variability in the response of GGT to alcohol use, which may result from genetic differences between individuals. This study aimed to ...