Gene Set Enrichment Analysis (GSEA) is a basic tool for genomic data treatment. Its test statistic is based on a cumulated weight function, and its distribution under the null hypothesis is evaluated by Monte-Carlo simulation. Here, it is proposed to subtract to the cumulated weight function its asymptotic expectation, then scale it. Under the null hypothesis, the convergence in distribution of...

We propose a new graph based strategy for the detection of spatial clusters of arbitrary geometric form in a map of geo-referenced populations and cases. Our test statistic is based on the likelihood ratio test previously formulated by Kulldorff and Nagarwalla for circular clusters. A new technique of adaptive simulated annealing is developed, focused on the problem of finding the local maxima ...

Cartograms combine statistical and geographical information in thematic maps, where areas of geographical regions (e.g., countries, states) are scaled in proportion to some statistic (e.g., population, income). Cartograms make it possible to gain insight into patterns and trends in the world around us and have been very popular visualizations for geo-referenced data for over a century. This wor...

We discuss and implement a new strategy for spatial cluster detection. A test statistic based on the likelihood ratio is used, as formulated by Kulldorff and Nagarwalla. Differently from these authors, our test is not restricted to the detection of clusters with fixed shape, such as rectangular or circular shape, but it looks for connected clusters with arbitrary geometry. This could be advanta...

The China-Pakistan Economic Corridor (CPEC) is a multi-billion-dollar collection of ongoing and planned Chinese projects in Pakistan ranging from infrastructure development to the establishment special economic zones sharing technical expertise by China. For China, it an integral part its ambitious Belt Road Initiative (BRI) through which aims establish hegemony Eurasia Africa. Pakistan, opport...

With the rise of China and the implementation of the “21st Century Maritime Silk Road” strategy, research on geo-economics between China and ASEAN (Association of Southeast Asian Nations) countries has become increasingly important. Current studies mainly focus on influencing factors, while there is little consideration about how these influencing factors act on geo-economic relationships. Ther...

BACKGROUND The World Health Organization has declared tuberculosis a global emergency in 1993. It has been estimated that one third of the world population is infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. The emergence of TB/HIV co-infection poses an additional challenge for the control of tuberculosis throughout the world. The World Health Organization is suppo...

The mass spectromctnc study of the vaporization of the compounds GeO (hex) and GeO(am) and of the mixture GeO (hex) + Ge(c) made it *Z possible to establish their mode of vaporization: Ge02(hex) GeO(g) + 1/20 (I) n GeO(am) (GeO) (g) (n 1. 2. 3) (II) n n/2 GeOJhex) + n/2 Ge(c) (GeO) (g) (n = 1,2,3) (III) c. n The enthalpies of vaporization are AH° (I) 121. 2± 1.6 kcal/mole AH» (II, n=l) = 53.4 ±...