نتایج جستجو برای: genotoxic
تعداد نتایج: 7494 فیلتر نتایج به سال:
The present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of Hypericum retusum AUCHER. The amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by HPLC. Total phenolic content of H. retusum seed extract was found more than fru...
Padina pavonica (Linnaeus) Thivy 1960 is a brown algae that antioxidant, antimicrobial, and anticancer effects generally used in soup, salad, other dishes. However, no studies have been reported on safe consumption humans to date. For this purpose, study was conducted determine the cytotoxic genotoxic of P. lymphocytes cultured from human blood. The water extract added into culture tubes at var...
the present study investigates the antioxidant, anticancer, anticholinesterase, anti-genotoxic activities and phenolic contents of flower, fruit and seed methanol extracts of hypericum retusum aucher. the amounts of protocatechuic acid, catechin, caffeic acid and syringic acid in methanol extracts were determined by hplc. total phenolic content of h. retusum seed extract was found more than fru...
In this study we evaluated the genotoxic potential of surface sediment extracts of Lake Skadar using a combination of two in vitro tests: the Comet assay on the fibroblast-like permanent cell line RTL-W1, and the Ames test on the strain Salmonella typhimurium TA98. The obtained results show that both tests were successful in determining the genotoxic potential in the sediment organic fractions....
In this study, the biological properties of novel borenium and borinium compounds in terms their oxidative, genotoxic, cytotoxic effects were assessed on cultured human peripheral blood cells, as well several types cancer cells. Our results revealed that yielded best supporting total antioxidant capacity (TAC). fact, 1, 2, 3, 4, 5 elevated TAC levels cells at rates 42.8%, 101.5%, 69.8%, 33.3%, ...
The EU FP6 project carcinoGENOMICS explored the combination of toxicogenomics and in vitro cell culture models for identifying organotypical genotoxic- and non-genotoxic carcinogen-specific gene signatures. Here the performance of its gene classifier, derived from exposure of metabolically competent human HepaRG cells to prototypical non-carcinogens (10 compounds) and hepatocarcinogens (20 comp...
Genotoxic compounds induce genetic mutations and/or chromosomal rearrangements and can therefore act as carcinogenic compounds (McGovern and Jacobson-Kram, 2006). These compounds cause damage to DNA by different mechanisms such as alkylation or other interactions that can lead to mutation of the genetic codes. In general, chemists employ the terms "genotoxic" and "mutagenic" synonymously; howev...
The existing systems of classification of carcinogens should include a distinction between genotoxic and non-genotoxic chemicals. For non-genotoxic chemicals, permissible exposure levels can be derived at which no relevant human cancer risks are anticipated. While genotoxic carcinogens can induce chromosomal effects without mutagenic action, non-DNA-reactive genotoxins affecting topoisomerase o...
DNA damage-induced activation of the transcription factor NF-κB plays an important role in the cellular response to genotoxic stress. However, uncontrolled NF-κB activation upon DNA damage may lead to deleterious consequences. Although the mechanisms mediating genotoxic NF-κB activation have been elucidated, how this signalling is terminated remains poorly understood. Here, we show that the CCC...
Genotoxic substances are those which capable to induce a destructive effect on cell’s genetic material. It can be either carcinogen, mutagen, teratogen or cytotoxic depending upon the dose, duration and mode of usage. Mutations may manifest in many forms as duplication, deletion insertion. However, all mutagens genotoxic, not genotoxins mutations. Currently traditional medicines plant drugs use...
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