Ehlers Danlos syndrome (EDS) is an inherited connective tissue disease due to impaired collagen metabolism. Joint hypermobility and skin hyper extensibility are the major findings. Six types of EDS are recognized. Type I or Gravis type is characterized by skin hyperextensibility, joint hypermobility, skin splitting autosoml dominancy inheritance, preterm premature rupture of membrane (PPROM) an...

Two hundred and fifty six consecutively ambulant diabetic patients attending a Nigerian diabetic clinic for the presence of cheiroarthropathy were examined using standard criteria. Forty eight (19%) had limited joint mobility of the hand, a prevalence higher than the 4% (2/56) observed in a non-diabetic population matched for age and sex. Limited joint mobility was twice as prevalent in the ins...

High mobility group AT-hook 1 (HMGA1) protein is an oncogenic architectural transcription factor that plays an essential role in early development, but it is also implicated in many human cancers. Elevated levels of HMGA1 in cancer cells cause misregulation of gene expression and are associated with increased cancer cell proliferation and increased chemotherapy resistance. We have devised a str...

normal range of joint motion is an important factor in joint examination in clinical practice which is related to factors such as age, sex and geographic region. there is no data in the literature on the range of joint motions in healthy iranian adults. we studied joint motions in 100 healthy volunteer subjects, 49 men and 51 women, from 19 and 58 years of age. the joint mobility was examined i...

Forty-two of 115 patients with Type I (insulin dependent) diabetes were found to have limited joint mobility affecting mainly the small joints of the hands. The presence of joint abnormalities was related to duration of diabetes. Patients with limited joint mobility had a significantly higher incidence of proliferative retinopathy than patients with normal joint mobility and a similar duration ...

This study identified which residual-limb quality factors are related to functional mobility 1 year after transtibial (TT) amputation. A group of 28 TT amputees were evaluated with respect to their functional mobility (Prosthesis Evaluation Questionnaire [PEQ], Locomotor Index, Timed Up and Go test). The general (Chakrabarty score) and bony (tibial length, relative fibular length) residual-limb...

Limited finger joint mobility was assessed in 112 diabetic children, in their first-degree relatives, and in 50 unrelated non-diabetic children. In 42% of the diabetic children there was limited joint mobility, but 14% of them had more severe involvement. Limited joint mobility was correlated with increasing age, early presentation, and longer duration of diabetes. First-degree relatives of aff...

We present a new mechanical design for a compact three degrees-of-freedom joint mechanism. This joint design is ideal for use in robotic devices, especially hyper-redundant or snake-like robots. This joint exhibits an unprecedented range of motion: the origin of a coordinate frame attached to the output link of the joint can move on a spherical cone whose apex angle is 120 and this coordinate f...