نتایج جستجو برای: gene tb

تعداد نتایج: 1164898  

Journal: : 2023

The objective: to study the genetic determinants of rifampicin resistance Mycobacterium tuberculosis by sequencing RRDR rpoB gene. Subjects and Methods. included 651 M. isolates that were tested for drug suceptibility (DST) genotypic methods (gDST) TB-TEST (BIOCHIP-IMB, Russia), Amplitube-MDR-RV (NPK Sintol, Russia) phenotypic (phDST): absolute concentration method, BACTEC MGIT 960 system, Sens...

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Journal: :Zoonoses 2022

The human immunodeficiency virus (HIV) pandemic has caused a resurgence of tuberculosis (TB), thus increasing morbidity and mortality. Moreover, HIV-TB coinfection leads to difficulties in diagnosis. Sputum smear microscopy, mycobacterial culture GeneXpert MTB/RIF assays are generally endorsed detect Mycobacterium ( M. ) coinfection. However, these methods cannot diagnose TB an accurate timely ...

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Journal: Iranian Journal of Pathology 2018
Aida Gholoobi, Ehsan Aryan, Faria Hasanzadeh Haghighi, Mohammad Derakhshan, Zahra Meshkat,

Background & objective:  Tuberculosis (TB) remains a major cause of death around the world. Bacillus Calmette Guérin (BCG) is the only vaccine used in TB prevention that has a protective effect in children, but its effectiveness declines in adults. Design and development of new vaccines is the most effective way against TB. The aim of this study was to design and construc...

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2013
Fang Wu Wanjiang Zhang Le Zhang Jiangdong Wu Chunzhu Li Xianjie Meng Xi Wang Peng He Jie Zhang

BACKGROUND To explore the potential role of natural-resistance-associated macrophage protein 1 (NRAMP1) gene, vitamin D receptor (VDR) gene, (human leukocyte antigen, (HLA-DRB1) HLA)-DRB1 gene, and HLA-DQB1 gene polymorphisms in susceptibility to tuberculosis (TB) in the Chinese Kazakh population. METHODS A case-control study was performed on the Chinese Kazak population. Genetic polymorphism...

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Journal: :EMBO molecular medicine 2016
Jeroen Maertzdorf Gayle McEwen January Weiner Song Tian Eric Lader Ulrich Schriek Harriet Mayanja-Kizza Martin Ota John Kenneth Stefan He Kaufmann

There is an urgent need for new tools to combat the ongoing tuberculosis (TB) pandemic. Gene expression profiles based on blood signatures have proved useful in identifying genes that enable classification of TB patients, but have thus far been complex. Using real-time PCR analysis, we evaluated the expression profiles from a large panel of genes in TB patients and healthy individuals in an Ind...

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2014
Kinuyo Chikamatsu Akio Aono Hiroyuki Yamada Tetsuhiro Sugamoto Tomoko Kato Yuko Kazumi Kiyoko Tamai Hideji Yanagisawa Satoshi Mitarai

BACKGROUND The rapid identification of acid-fast bacilli recovered from patient specimens as Mycobacterium tuberculosis complex (MTC) is critically important for accurate diagnosis and treatment. A thin-layer immunochromatographic (TLC) assay using anti-MPB64 or anti-MPT64 monoclonal antibodies was developed to discriminate between MTC and non-tuberculosis mycobacteria (NTM). Capilia TB-Neo, wh...

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Journal: :Antibiotics 2023

The emergence of pre-extensively drug-resistant tuberculosis (pre-XDR-TB) is a threat to TB control programs in developing countries such as Zambia. Studies Zambia have applied molecular techniques understand drug-resistance-associated mutations, circulating lineages and transmission patterns multi-drug-resistant (MDR) Mycobacterium tuberculosis. However, none has reported genotypes mutations a...

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2014
Adane Mihret Andre G Loxton Yonas Bekele Stefan HE Kaufmann Martin Kidd Mariëlle C Haks Tom HM Ottenhoff Abraham Aseffa Rawleigh Howe Gerhard Walzl

BACKGROUND Genetic factors are involved in susceptibility or protection to tuberculosis (TB). Apart from gene polymorphisms and mutations, changes in levels of gene expression, induced by non-genetic factors, may also determine whether individuals progress to active TB. METHODS We analysed the expression level of 45 genes in a total of 47 individuals (23 healthy household contacts and 24 new ...

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2017
Ethan G. Thompson Ying Du Stephanus T. Malherbe Smitha Shankar Jackie Braun Joe Valvo Katharina Ronacher Gerard Tromp David L. Tabb David Alland Shubhada Shenai Laura E. Via James Warwick Alan Aderem Thomas J. Scriba Jill Winter Gerhard Walzl Daniel E. Zak Nelita Du Plessis Andre G. Loxton Novel N. Chegou Myungsun Lee

Biomarkers for tuberculosis treatment outcome will assist in guiding individualized treatment and evaluation of new therapies. To identify candidate biomarkers, RNA sequencing of whole blood from a well-characterized TB treatment cohort was performed. Application of a validated transcriptional correlate of risk for TB revealed symmetry in host gene expression during progression from latent TB i...

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Journal: :PLOS ONE 2015

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