about electronic signatures there are more or less some writings concerning their legal aspect. but in those writings there has been a little attention to credibility and evidential value of the electronic signatures. some questions and ambiguities despite being set before has not been answered at all or answered unsatisfactorily. meanwhile, some authors have made mistakes and some have set tri...

PURPOSE This study aimed to identify and validate a gene expression signature for squamous cell carcinoma of the lung (SQCC). EXPERIMENTAL DESIGN A published microarray dataset from 129 SQCC patients was used as a training set to identify the minimal gene set prognostic signature. This was selected using the MAximizing R Square Algorithm (MARSA), a novel heuristic signature optimization proce...

this article concerned on the study of signature submanifolds for curves under lie group actions se(2), sa(2) and for surfaces under se(3). signature submanifold is a regular submanifold which its coordinate components are dierential invariants of an associated manifold under lie group action, and therefore signature submanifold is a key for solving equivalence problems.

Hepatocellular carcinoma (HCC) is a common immunogenic malignant tumor. Although the new strategies of immunotherapy and targeted therapy have made considerable progress in treatment HCC, 5-year survival rate patients still very low. The identification prognostic signatures exploration immune microenvironment are crucial to optimization improvement molecular strategies. We studied potential cli...

Colorectal cancer patients with the BRAF(p.V600E) mutation have poor prognosis in metastatic setting. Personalized treatment options and companion diagnostics are needed to better treat these patients. Previously, we developed a 58-gene signature to characterize the distinct gene expression pattern of BRAF-mutation-like subtype (accuracy 91.1%). Further experiments repurposed drug Vinorelbine a...

Late allograft failure is characterized by cumulative subclinical insults manifesting over many years. Although immunomodulatory therapies targeting host T cells have improved short-term survival rates, rates of chronic allograft loss remain high. We hypothesized that other immune cell types may drive subclinical injury, ultimately leading to graft failure. We collected whole-genome transcripto...