Inactivation of tumor suppressor genes is a frequent event in carcinogenesis. In skin cancer, the CDKN2A gene, which encodes p16INK4A and p14ARF proteins, often silenced by epigenetic abnormalities such as promoter DNA methylation histone deacetylation. The cell cycle regulator plays key role growth metastasis. Unlike gene loss, silencing aberrant modifications can be reversed small-molecule co...

Mechanical stimulation is capable of affecting cell apoptosis. Several studies have shown that the Bcl-2 gene family, including and Bax gene, plays an important role in apoptosis, as proteins produced by can inhibit apoptosis while promote Understanding how mechanical alters expression apoptosis-related genes cardiomyocytes contribute to development ways cardiomyocyte necrosis. Intermediate myo...

development of inhibitor to factor viii is the most serious complication of hemophilia therapy. to determine the prevalence of inhibitors in iran hemophilia a patients exposed to blood products, 1280 hemophilia a patients (age range 9 months-84 years) were evaluated. all patients received several blood products such as fresh frozen plasma (ffp), cryoprecipitate, and factor viii. 635 of 1280 pat...

Background: Chronic myeloid leukemia is a clonal myeloproliferative disease which is characterized by bcr/abl translocation. With the emergence of tyrosine kinase inhibitors such as imatinib mesylate, significant improvement has been made in treatment of this disease. However, drug resistance against this medicine is still an obstacle. SIRT1 is a gene with deacetylase activity which has been de...

The β2-adrenergic receptor, located in the prostate region, binds noradrenaline and can influence growth of tumors. removal Adrb2, gene for this halt tumor thus serve as an alternative to chemotherapy cancer treatment. Inhibition receptor may have similar effects. Comparison β2- (PDB ID: 5X7D) β1-adrenergic 2Y04) structures showed a conserved binding region on Chain A offset by approximately ei...

Oncolytic viruses are a type of virus that infects and kills tumor cells more than other cells. They act as “immune modification platforms” express immune checkpoint inhibitors, antigens, cytokines, T cell engagers. can be engineered or tested to selectively multiply kill cancer Targeting strategies include deleting the gene for virulence factor using abnormal signaling pathways in stop them fr...

Activating stimulator of interferon genes to turn immunologically refractive cold tumor hot is an exciting therapeutic approach increase the clinical responsiveness some human cancers immune checkpoint inhibitors. DNA damaging drugs and PARP inhibitors are two types agents that have demonstrated this potential. Inhibitors Chk1 or Wee1 induce damage in cancer cells predominantly S-phase populati...

Abstract Background The fermentation of lignocellulose hydrolysates to ethanol requires robust xylose-capable Saccharomyces cerevisiae strains able operate in the presence microbial inhibitory stresses. This study aimed at developing industrial S. with enhanced tolerance towards pretreatment-derived inhibitors, by identifying novel gene combinations that confer resistance multiple inhibitors (t...