The rate of transcription of several genes encoding proteins involved in O2 and energy homeostasis is controlled by hypoxia-inducible factor-1 (HIF-1), a heterodimeric DNA binding complex composed of a and b subunits. HIF-1 is considered the primary trans-acting factor for the erythropoietin (EPO) and vascular endothelial growth factor (VEGF) genes. Since EPO gene expression is inhibited by the...

The aim of the study was to evaluate gene expression proinflammatory cytokines in esophageal mucosa patients with erosive esophagitis (EE) and non-erosive form (NERD) gastroesophageal reflux disease (GERD) perform correlation analysis between genes types number refluxes. Methods. This a single-center prospective study. Esophageal samples were taken from lower part esophagus during endoscopy. Ex...


 Psoriasis is a chronic, inflammatory condition that primarily affects the skin, hair, and joints associated with significant humanistic economic consequences. was induced in mice this work using an imiquimod 5% cream, immune response modifier can cause psoriasis-like skin inflammation when given orally. Paquinimod prepared as suspension has been orally to before application. The current ...

Adrenomedullin (ADM) is a potent hypotensive peptide produced by macrophages and endothelial cells during ischemia and sepsis. The molecular mechanisms that control ADM gene expression in tumor cells are still poorly defined. It is known, however, that hypoxia potently increases ADM expression by activation of the transcription factor complex hypoxia inducible factor 1 (HIF-1). Proinflammatory ...

background and aims: several studies have shown that there is greater number of viruses in deep periodontal pockets than in normal gingival sulcus. we also know that virus may have an important role in induction of il-1β secretion by different human cells. in this study we intended to determine the capacity of herpes simplex virus type 1 to stimulate il-1β secretion in human gingival keratinocy...

Today, the use of oak as a replacement feed in poultry diets is well documented. However, oak contains polyphenol compounds (tannins) as antinutrient factors resulted in limited usage in the poultry rations. Generally, consumption of feeds containing tannin could affect gene expression level of immune system. Therefore, the aim of this study was to investigate the effect of different levels of ...

Inflammation appears to play an important role in the repair and regeneration of skeletal muscle after damage. We tested the hypothesis that the severity of the inflammatory response in muscle after an acute bout of resistance exercise is associated with single nucleotide polymorphisms (SNPs) previously shown to alter interleukin-1 (IL-1) activity. Using a double-blind prospective design, seden...

Nitric oxide (NO) is known to have antiatherogenic and anti-inflammatory properties, but its effects on the cytokine-induced nuclear factor-kappa B (NF-kB) activation pathway in relation to the regulation of inducible nitric oxide synthase (iNOS) gene in vascular smooth muscle cells (VSMCs) remain elusive. To elucidate the roles of NO in the regulation of cytokine-induced NF-kB activation and c...

Introduction: Pro-inflammatory cytokines, such as IL-1b and TNF- α have been suggested to be involved in the pathophysiology of depression. Tricyclic antidepressants (TCAs) are also thought to influence immune functions and concentrations of cytokines. The aim of this study was to evaluate the status of serum IL-1b and TNF-α in depressed patients who were treated, not treated, or poisoned wit...