Carvedilol is administered as a racemic mixture of the R(+)- and S(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. The aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. Stereoselective interact...

BACKGROUND It has been suggested that dysfunctional attitudes, cognitive vulnerability to depression, have developmental origins. The present study examined the effects of parental rearing on dysfunctional attitudes in three areas of life with special attention to gender specificity. METHODS The subjects were 665 Japanese healthy volunteers. Dysfunctional attitudes were assessed by the 24-ite...

carvedilol is administered as a racemic mixture of the r(+)- and s(-)-enantiomers, although it was demonstrated that the two enantiomers exhibit different pharmacological effects and stereoselective pharmacokinetics. the aim of this study was the evaluation of several native and derivatized cyclodextrines as chiral selectors for the separation of carvedilol enantiomers. stereoselective interact...

In moving from concepts of motherhood and mothers to a theorisation of maternal subjectivity that emphasises unconscious intersubjectivity, this paper casts light on the following questions: ⇒ What is meant by maternal and who qualifies? ⇒ Do gender and sex of parents and carers make any systematic difference to an infant, child or adolescent’s experience of parenting and their own capacity to ...

Empirical research had initially shown that English listeners are able to identify the speakers' sexual orientation based on voice cues alone. However, the accuracy of this voice-based categorization, as well as its generalizability to other languages (language-dependency) and to non-native speakers (language-specificity), has been questioned recently. Consequently, we address these open issues...

This article investigates how dispersed settlement in areas of urban sprawl affects the structure of personal networks that in turn influences the likelihood of social integration among male and female immigrants from Taiwan. Settlement in the deconcentrated spaces that currently constitute the new urban spaces of U.S. metropolitan areas potentially offers more opportunities to interact with et...

BACKGROUND Insight in the natural course of care dependency of vulnerable older persons in long-term care facilities (LTCF) is essential to organize and optimize individual tailored care. We examined changes in care dependency in LTCF residents over two 6-month periods, explored the possible predictive factors of change and the effect of care dependency on mortality. METHODS A prospective fol...