نتایج جستجو برای: gelatinases

تعداد نتایج: 2269  

Journal: :The European respiratory journal 2008
P Glader B Eldh S Bozinovski K Andelid M Sjöstrand C Malmhäll G P Anderson G C Riise I Qvarfordt A Lindén

Clinical studies have indicated increased gelatinase activity in the airways of patients suffering from chronic obstructive pulmonary disease caused by tobacco smoke. The present study aimed to determine whether acute exposure to tobacco smoke per se causes a substantial and lasting impact on gelatinases and their inhibitors in the peripheral airways of atopic and nonatopic human subjects. Bron...

2015
Bridgette D. Semple Linda J. Noble-Haeusslein Major Gooyit Kayleen G. Tercovich Zhihong Peng Trung T. Nguyen Valerie A. Schroeder Mark A. Suckow Mayland Chang Jacob Raber Alpa Trivedi Firas H Kobeissy

The gelatinases, matrix metalloproteinases (MMP)-2 and MMP-9, are thought to be key mediators of secondary damage in adult animal models of brain injury. Moreover, an acute increase in these proteases in plasma and brain extracellular fluid of adult patients with moderate-to-severe traumatic brain injuries (TBIs) is associated with poorer clinical outcomes and mortality. Nonetheless, their invo...

Journal: :Japanese journal of ophthalmology 2003
Tohru Sakimoto Jun Shoji Mitsuru Sawa

PURPOSE To investigate the expression of the active form of gelatinases (gelatinase A: matrix metalloproteinase-2 [MMP-2] and gelatinase B: matrix metalloproteinase-9 [MMP-9]) in ocular surface disorders, we determined the presence of the active form of these gelatinases in the tear fluid of patients with corneal ulcer or ocular burn. METHODS The subjects consisted of the ulcer group comprisi...

Journal: :Journal of immunology 1999
K C Fang P J Wolters M Steinhoff A Bidgol J L Blount G H Caughey

Our prior work shows that cultured BR cells derived from dog mastocytomas secrete the 92-kDa proenzyme form of gelatinase B. We provided a possible link between mast cell activation and metalloproteinase-mediated matrix degradation by demonstrating that alpha-chymase, a serine protease released from secretory granules by degranulating mast cells, converts progelatinase B to an enzymatically act...

Journal: :Folia biologica 2017
K Gopcevic B Rovcanin D Kekic D Milasinovic G Kocic I Stojanovic

Oxidative stress plays important roles in the pathophysiology of acute myocardial infarction (AMI). The aim of this study was to investigate the correlation of the oxidative stress status and matrix metalloproteinase activity in AMI patients in comparison to controls. This study included 136 subjects: 68 patients with AMI (42 males/26 females; mean age 58.5 ± 10.5 years) and 68 controls (37 mal...

Journal: :The EMBO journal 1997
R Mazzieri L Masiero L Zanetta S Monea M Onisto S Garbisa P Mignatti

The urokinase-type plasminogen activator (uPA) and the matrix-degrading metalloproteinases MMP-2 and MMP-9 (type IV collagenases/gelatinases) have been implicated in a variety of invasive processes, including tumor invasion, metastasis and angiogenesis. MMP-2 and MMP-9 are secreted in the form of inactive zymogens that are activated extracellularly, a fundamental process for the control of thei...

Journal: :Bioorganic & medicinal chemistry 2011
Jun Wang Carlos Medina Marek W Radomski John F Gilmer

Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5,5-Disubstituted barbiturates hold promise as inhibitor types being stable in vivo and relatively selective for the gelatinases (MMP-2 and MMP-9). In this paper we describe the synthesis of 5-piperazine and -homopiperazine sub...

Journal: :Biochimica et biophysica acta 2005
Mikael Björklund Erkki Koivunen

The matrix metalloproteinases(MMP)-2 and -9, also known as the gelatinases have been long recognized as major contributors to the proteolytic degradation of extracellular matrix during tumor invasion. In the recent years, a plethora of non-matrix proteins have also been identified as gelatinase substrates thus significantly broadening our understanding of these enzymes as proteolytic executors ...

Journal: :The American journal of pathology 1998
A Pardo R Barrios V Maldonado J Meléndez J Pérez V Ruiz L Segura-Valdez J I Sznajder M Selman

Subacute hyperoxia may cause basement membrane disruption and subsequent fibrosis. To test the role of extracellular matrix degradation in hyperoxic damage, we analyzed the expression of gelatinases A and B and tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 in rats exposed to 85% O2. Oxygen-exposed rats were studied at 1, 3, 5, and 7 days, and compared with air-breathing rats. Lung...

Journal: :The international journal of biochemistry & cell biology 2001
M Nguyen J Arkell C J Jackson

Endothelial cell invasion is an essential event during angiogenesis (formation of new blood vessels). The process involves the degradation of the basement membrane and the underlying interstitium. The matrix metalloproteinase (MMP) family is considered to be primarily responsible for matrix degradation. Two members of the family, gelatinase A and B play an important role in angiogenesis. This r...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید