BACKGROUND Osteoblastoma is a rare and benign osteoid-producing primary bone tumor that affects mainly the long bones. 36% of these tumors are observed around the spine and the vast majority arises around the posterior. CASE PRESENTATION This report describes a case of C3-4 osteoblastoma occurring in a 5-year-and-8-month-old Han Chinese child. The pathophysiology of symptom development, evalu...

BACKGROUND The lymphatic system controls tissue homeostasis by draining protein-rich lymph to the vascular system. Lymphangiogenesis, the formation of lymphatic vessels, is a normal event in childhood but promotes tumor spread and metastasis during adulthood. Blocking lymphangiogenesis may therefore be of therapeutic interest. Production of adenosine is enhanced in the tumor environment and con...

The poly(lactide-co-glycolide) (PLGA) sponge fabricated by a gelatin porogen leaching method was filled with fibrin gel to obtain a hybrid scaffold for chondrocytes culture in vitro. The fibrin gel evenly distributed in the hybrid scaffold with visible fibrinogen fibers after drying. In vitro culture it was found that in the hybrid scaffold the chondrocytes distributed more evenly and kept a ro...

Activated T lymphocytes play a crucial role in orchestrating cellular infiltration during a cell-mediated immune (CMI) reaction. TCA3, a C-C chemokine, is produced by Ag-activated T cells and is chemotactic for neutrophils and macrophages, two cell types in a murine CMI reaction. Using a gelatin sponge model for delayed-type hypersensitivity (DTH), we show that TCA3 is a component of the expres...

Need for regeneration and repair of nasal tissues occurs as a consequence several pathologies affecting the nose, including, but not limited to infective diseases, traumas tumor resections. A platform tissue was set up using poly(vinyl alcohol)/gelatin sponges with 20%–30% (w/w) gelatin content be used scaffolds, their intrinsic hydrophilic, cell adhesive shape recovery properties. We propose m...

Marine sponges are extremely rich in natural products and are considered a promising biological resource. The major objective of this work is to couple a green extraction process with a natural origin raw material to obtain sponge origin collagen/gelatin for biomedical applications. Marine sponge collagen has unique physicochemical properties, but its application is hindered by the lack of avai...

The Dunning R-3327 rat prostatic adenocarcinoma is a widely accepted model for in vivo experimental studies of prostate cancer. We have previously derived phenotypically distinct cell lines from a s.c. tumor resulting from the inoculation of the R-3327-5 subclone into Copenhagen rats. In this study, we report studies using a gelatin sponge model for the delivery of tumor cells and the retrieval...

Nasal packing materials are widely used in endonasal surgery, including septoplasty, turbinoplasty and paranasal sinus surgery. They are also used to prevent synechiae and haematoma formation, to support septal flap apposition, and to close dead space between cartilage and subperichondrial flaps [1]. Several types of nasal packs are used post-operatively in nasal and sinus surgery. There are va...

Background: The use of absorbable gelatin sponges (AGSs) as a hemostatic surgical material resulted in reduction dry sockets occurrence. systemic antibiotics and antimicrobial agents can also reduce the infection extracted teeth, therefore, it may show pain-relieving effects on socket well. Objective: Given high prevalence main objective this review was brief overview AGSs, including to prevent...