Objective: A relationship between glial cell line-derived neurotrophic factor (GDNF) and the etiology of schizophrenia (SCH) bipolar disorder (BD) has been reported. GDNF, in addition to other factors, may play a role mechanism action electroconvulsive treatment (ECT). The primary objective this study was investigate effect ECT on serum GDNF levels before after administration ECT. Method: Thirt...

Parkinson's disease (PD) is a degenerative disease of the central nervous system (CNS) predominantly occurring in older adults, and is particularly common after the age of 60. The primary pathologic characteristics of PD are neuronal degeneration and cell death of dopaminergic (DA-ergic) neurons, leading to a decrease in the dopamine (DA) level in the striatum. Originally extracted and purified...

Royal jelly (RJ) is known to have a variety of biological activities toward various types of cells and tissues of animal models, but nothing is known about its effect on brain functions. Hence, we examined the effect of oral administration of RJ on the mRNA expression of various neurotrophic factors, their receptors, and neural cell markers in the mouse brain. Our results revealed that RJ selec...

Glial cell line-derived neurotrophic factor (GDNF) mRNA is highly expressed by dental pulp cells (DPCs) prior to the initiation of dental pulp innervation. We show that radioactively labelled exogenous GDNF is retrogradely transported from neonatal teeth and vibrissae to the trigeminal neurons, indicating that GDNF acts as a classical neurotrophic factor in the trigeminal system. We also show t...

The glial cell line-derived neurotrophic factor (GDNF) is a secreted protein, best known for its role in the development of the central and peripheral nervous systems and the survival of adult dopaminergic neurons. More recently, accumulating evidence suggests that GDNF plays a unique role in negatively regulating the actions of drugs of abuse. In this article, we review these data and highligh...

This study investigated the effects of glial cell line-derived neurotrophic factor (GDNF) on dental pulp stromal cells (DPCs). Cultures of DPCs expressed GDNF as well as its receptors, GFR1 and RET. Addition of recombinant GDNF to cultures in serumcontaining medium did not significantly affect DPC growth; however, GNDF dosedependently increased viable cell number under serum-free culture condi...

Background: Some clinical studies have reported the alteration of serum brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) level before and after the antidepressant treatments in patients with major depressive disorder (MDD). We evaluated serum BDNF and GDNF levels before and after the 12-week antidepressant treatments in MDD outpatients. Methods: Se...

Background: Some clinical studies have reported the alteration of serum brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) level before and after the antidepressant treatments in patients with major depressive disorder (MDD). We evaluated serum BDNF and GDNF levels before and after the 12-week antidepressant treatments in MDD outpatients. Methods: Se...