Transdermal drug delivery system (TDDS) is not practicable for delivery of materials whose final target is skin itself. Controlled release of drugs onto the epidermis with assurance that the drug remains primarily localized and does not enter the systemic circulation in significant amounts is a challenging area of research. Microsponges are highly porous micro-sized particles with a unique abil...

In the field of drug delivery system, there are numerous new formulation techniques. Microsponge one most recent novel technique which gaining popularity now days due to their use controlled release and targeted system. technology offers entrapment ingredient is believed contribute towards reduced side effect, improved stability, increase elegance enhanced flexibility. addition, microsponges no...

A biphasic gastroretentive drug delivery system of fenoverine was developed to maintain constant plasma concentration. The delivery system consisted of a loading-dose tablet and a floating multiple matrix tablet prepared by the direct compression process. The drug release from biphasic GRDDS in 0.1 mol L(-1) HCl and SGF (enzyme free) was sustained over 12 h with buoyant properties. Stability st...

BACKGROUND AND THE PURPOSE OF THE STUDY Many drugs which have narrow therapeutic window and are absorbed mainly in stomach have been developed as gastroretentive delivery system. Rosiglitazone maleate, an anti-diabetic, is highly unstable at basic pH and is extensively absorbed from the stomach. Hence there is a need to develop a gastroretentive system. In this study a superporous hydrogel was ...

Invasive fungal infections can be devastating, especially in immunocompromized patients. Oral administration of fluconazole (FLZ) often produces gastric irritation, heart-burn, vomiting and sometimes patient can develop ulceration resulting in a less patient compliance with long term therapy. The aim of the present study was to formulate topical microsponge-based delivery system containing FLZ ...

      Benzoyl peroxide (BPO) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. Skin irritation is a common side effect, and it has been shown that controlled release of BPO from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. Therefore, the purpose of t...

Background: Microsponge is a class of dosage form containing porous nature drug that targeted to achieve sustained action for prolong period. based delivery system results in localization on skin surface and epidermis without moving systemic circulation higher extent. Methods: Present study aims formulate the microsponge celecoxib by quasi emulsification solvent diffusion method. Prepared formu...

Objective: The objective of the present work was to formulate a gastroretentive dosage form of Valacyclovir, an anti viral drug. Methods: Valacyclovir gastroretentive mucoadhesive tablets were prepared using polymers such as Carbopol 974P and hydroxy propyl methyl cellulose (HPMC) K4M, in different proportions by wet granulation technique. Compatibility studies were performed by FTIR spectrosco...

Site specific drug delivery has become the important aspect of research. In present study focused has been made to formulate gastroretentive drug delivery (GRDDS) of drugs having narrow absorption window or having good absorption at proximal part of gastrointestinal tract (GIT) to deliver at stomach site. Hydrogel based gastroretentive formulation of ramipril were prepared by gas blowing techni...

benzoyl peroxide (bpo) is a first-line topical treatment in acne vulgaris, and it is superior to antibiotics, because the bacteria do not develop resistance to it. skin irritation is a common side effect, and it has been shown that controlled release of bpo from a delivery system to the skin could reduce the side effects while reducing percutaneous absorption. therefore, the purpose of the pres...