Nitric oxide has been suggested as a contributor to tissue injury in various experimental models of gastrointestinal inflammation. However, there is overwhelming evidence that nitric oxide is one of the most important mediators of mucosal defence, influencing such factors as mucus secretion, mucosal blood flow, ulcer repair and the activity of a variety of mucosal immunocytes. Nitric oxide has ...

A small but meaningful percentage of men who are treated with external beam radiation therapy for prostate cancer will develop late gastrointestinal toxicity. While numerous strategies to prevent gastrointestinal injury have been studied, clinical trials concentrating on late toxicity have been difficult to carry out. Identification of subjects at high risk for late gastrointestinal injury coul...

Treatments with nonsteroidal anti-inflammatory drugs (NSAIDs) have increased the number of patients with gastrointestinal complications. Qing Dai has been traditionally used in Chinese herbal medicine for various inflammatory diseases such as ulcerative colitis. We previously reported that Qing Dai suppressed inflammations by scavenging reactive oxygen species (ROS) in ulcerative colitis patien...

In this study, we aimed to determine gastrointestinal problems associated with neurogenic bowel dysfunction in spinal cord injury patients and to assess the efficacy of bowel program on gastrointestinal problems and the severity of neurogenic bowel dysfunction. Fifty-five spinal cord injury patients were included in this study. A bowel program according to the characteristics of neurogenic bowe...

Major differences are evident between Japanese and Western practice in the prevention of gastrointestinal injury caused by low-dose aspirin (LDA) and nonsteroidal anti-inflammatory drugs (NSAIDs). The proportion of physicians prescribing gastroprotective agents with NSAIDs and LDA with the aim of preventing gastrointestinal injury is 77% in Japan and between 7084% in Spain, showing the great ma...

BACKGROUND/AIMS This study was performed to determine whether low-dose aspirin and/or clopidogrel can induce gastrointestinal bleeding and gastroduodenal mucosal injury. METHODS A total of 387 patients who underwent coronary angiography at Seoul National University Bundang Hospital were assigned to one of three antiplatelet treatment groups: (1) control, (2) 100-mg enteric coated aspirin, and...

Background: Critically ill children admitted to pediatric intensive care unit (PICU) are at increased risk of gastrointestinal bleeding due to stress related mucosal injury. Reducing gastric acid by acid suppressant medication is the accepted prophylaxis treatment, but there is not any definitive guideline for using prophylaxis in PICU patients. The present study aimed to assess the effect of P...

Recall appropriate therapeutic recommendations with respect to cardiovascular and gastrointestinal patient risk factors. Educational Objectives strated a reduced risk of gastrointestinal mucosal injury. However, there appears to be a delicate balance between the ability to protect the gastric mucosa and the effect on thrombotic events. Although selective COX-2 inhibitors appear to protect the g...

The adaptability of the central nervous system has been revealed in several model systems. Of particular interest to system-injured individuals is ability for neural components be modified regain function. In both types neurotrauma, traumatic brain injury and spinal cord injury, primary parasympathetic control gastrointestinal tract, vagus nerve, remains anatomically intact. However, with or ar...

Background: Ingestion of caustic substances is the main reason for referral to Philippines National Poison Management and Control Center among other causes of acute poisoning. Rapid assessment of severity of injury is important for treatment and prognosis of these cases. This study was aimed to investigate the correlation of clinical factors with severity of gastrointestinal (GI) mucosal injury...