there are limited clinical investigations identifying the percentage of t helper 1 (th1) and t regulatory (treg) cells in stable as well as rejected kidney allografts, a concept which needs to be more studied. the aim of our study was to compare the percentage of cd4+ ifn-γ+ cells, the number of ifn-γ secreting cells and the amount of foxp3 expression in patients with or without stable graft fu...

the aim of this study was to investigate the possible influence of interferon-gamma (ifn- γ) gene polymorphism +874 (a/t) (rs2430561) in the susceptibility and renal complications of patients with henoch-schonlein purpura (hsp). we also studied the effects of ifn-γ allelic variation on serum levels of pro-and anti-inflammatory cytokines in hsp patients. the  study  population  comprised  97  pa...

Prior to the production of human gamma interferon using recombinant DNA technology, it had been producedmainly upon mitogenic induction of lymphocytes in very low amounts, which evidently hamperedits characterization and its medical applications. The recombinant gamma interferons produced in largerquantities in prokaryotic systems retain their biological activities, and can be...

BACKGROUND : Interferon-gamma (INF-γ) is an important cytokine in the immune response against Mycobacterium tuberculosis. activates macrophage to kill intracellular mycobacterium. AIM: The aim of this study determine difference plasma INF-γ level pulmonary tuberculosis (PTB) patients compared a healthy control and factors associated with interferon-gamma level. METHODS: This case–control study....

To determine if exogenous gamma interferon is effective in immunosuppressed mice infected with Trypanosoma cruzi, recombinant murine gamma interferon was administered to cyclosporin-treated mice with either acute or chronic T. cruzi infection. Gamma interferon significantly decreased parasitemia and prevented death in acutely infected mice. Parasitemias and mortality of mice treated with both g...

Ebola virus outbreaks, such as the 2014 Makona epidemic in West Africa, are episodic and deadly. Filovirus antivirals are currently not clinically available. Our findings suggest interferon gamma, an FDA-approved drug, may serve as a novel and effective prophylactic or treatment option. Using mouse-adapted Ebola virus, we found that murine interferon gamma administered 24 hours before or after ...

The effect of treating cultured mouse fibroblasts (L929 cells) with cloned mouse interferon-gamma on the growth of Rickettsia prowazekii within the fibroblasts was studied. Within 48 h after infection, rickettsiae were cleared from a substantial proportion of the initially infected cells and rickettsial growth was inhibited in those cells that remained infected, when L929 cells were treated wit...