The highly invasive and angiogenic characteristics of malignant gliomas depend on the production of growth factors and angiogenic factors. Heparin-binding growth-associated molecule (HB-GAM) is a secreted growth factor that is mitogenic for endothelial cells. To examine the expression profile of HB-GAM in malignant glioma cells, messenger ribonucleic acid (mRNA) expression was analyzed in 10 ma...

GAMs oscillate between states of strong rotation and up-down asymmetric plasma compression. Hence, at first glance the natural turbulent drive (or damping) mechanisms for them is either a direct boost of the rotation – via Reynolds stress – or the creation of asymmetric pressure distributions – via transport. However, an up-down asymmetric pressure can also be created by the divergence of the d...

In this study, per-person municipal expenditures were modeled as a function of six demographic and income-related variables, first using a robust linear regression model (LM), and second using a generalized additive model (GAM). A comparison of the two models revealed that the GAM provided more accurate predictions, and therefore we recommend for the client to use the GAM as the basis for predi...

The geodesic acoustic mode (GAM) is a high frequency branch of zonal flows, which is observed in toroidal plasmas. Because of toroidal curvature effects, density fluctuations are excited, which are investigated with the O-mode correlation reflectometer at TEXTOR. This Letter reports on the poloidal distribution of GAM induced density fluctuation and compares them with theoretical predictions. T...

As an extension of the traditional Land Use Regression (LUR) modelling, the generalized additive model (GAM) was developed in recent years to explore the non-linear relationships between PM2.5 concentrations and the factors impacting it. However, these studies did not consider the loss of information regarding predictor variables. To address this challenge, a generalized additive model combinin...

In silico analyses of previously sequenced strains of Escherichia coli O157:H7, EDL933 and Sakai, localized the gene cluster for the utilization of N-acetyl-D-galactosamine (Aga) and D-galactosamine (Gam). This gene cluster encodes the Aga phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) and other catabolic enzymes responsible for transport and catabolism of Aga. As the complete...

Heparin-binding growth-associated molecule (HB-GAM) is an extracellular matrix-associated protein implicated in the development and plasticity of neuronal connections of brain. Binding to cell surface heparan sulfate is indispensable for the biological activity of HB-GAM. In the present paper we have studied the structure of recombinant HB-GAM using heteronuclear NMR. These studies show that HB...

HB-GAM (heparin binding growth-associated molecule; pleiotrophin) is a secretory, extracellular matrix-associated protein that is strongly expressed in developing nervous tissues and belongs to a novel family of differentiation/growth factors. It promotes axonal growth from perinatal rat brain neurons and is suggested to be mitogenic for some cell types and to display cell-transforming activity...

The density fluctuation of Geodesic Acoustic Mode (GAM) zonal flow has been observed in Ohmic deuterium plasma discharges with Langmuir probe arrays on the HL-2A tokamak. The density fluctuation has the poloidal mode number m < 1 and toroidal mode number n ~ 0. Its amplitude is consistent with theoretic prediction as well. Bispectral analysis shows that the nonlinear interaction between the GAM...

This paper describes the use of the GAM procedure for fitting generalized additive models (Hastie and Tibshirani, 1990). PROC GAM, production in Release 8.2, provides an array of powerful tools for data analysis, incorporating nonparametric regression and smoothing techniques as well as generalized distributional modeling. Compared with other regression procedures such as PROC REG and PROC GLM,...