The current renaissance in main group chemistry has been fuelled by the remarkable array of fundamentally interesting yet synthetically applicable low oxidation state p-block compounds that have appeared over the last decade. Their syntheses generally require the ready availability of low oxidation state element halide precursors. In the case of gallium this is provided by the simple to prepare...

The Front Cover shows the major antineoplastic mechanisms of gallium compounds. Gallium, whose name originates from Latin word “Gallus (the Rooster)”, has been considered as one main-group elements potentially used in chemotherapy for decades. Gallium compounds, such Ga(NO3)3, inhibit tumors by relying on similarity between Ga3+ and Fe3+, latter which plays a crucial role enzyme catalysis redox...

The electronic structures of a series of gallium complexes are examined using X-ray absorption spectroscopy (XAS) in combination with ab initio calculations. The chemical states of Ga are strongly affected by the ligands and the bonding environment. For complexes containing multiple gallium sites, we demonstrate that XAS can identify the chemical state of each unique gallium center. A reliable ...

Metals and metal compounds have been used in medicine for several thousands of years. In this review we summarized the anti-cancer activities of the ten most active metals: arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium and platinum. The first reviewed metal, arsenic, presents the anomaly of displaying anti-cancer and oncogenic properties simultaneously. Some antim...

There is current interest in the bioinorganic chemistry of gallium owing to the extensive use of the element in medicine both as a therapeutic and diagnostic agent [1]. After numerous studies of simple gallium(III) salts [2, 3] recent investigations have focussed on coordination compounds of gallium halides with bio-relevant ligands including also many of the common nitrogen heterocycles [3, 4]...

Clinical studies have shown gallium nitrate to have significant antitumor activity against non-Hodgkin's lymphoma and bladder cancer, thus indicating that gallium-based drugs have potential for further development as antineoplastic agents. In this study, we compared the cytotoxicity of gallium maltolate, a novel gallium compound, with gallium nitrate in lymphoma cell lines, including p53 varian...