BACKGROUND Lifetime risk assessment tools are relatively limited in identifying breast cancer risk in younger women. The predictive value of mathematical models to estimate risk varies according to age, menopausal status, race/ethnicity, and family history. Current risk prediction models estimate population, not individual, levels of breast cancer risk; hence, individualized risk prediction mod...

Background: The Gail Model has been widely implemented in developed and developing countries and is considered to be the best available instrument to estimate breast cancer (BC) risk for early prevention. Objective: The goals of the study were to determine five-year and lifetime BC risks and to assess BC predictors among female Saudi teachers using the Gail model. Methods: A cross sectional stu...

Mammographic breast density is an established risk factor for breast cancer. However, results are inconclusive regarding its use in risk prediction models. The current study evaluated 13,409 postmenopausal participants in the NSABP Study of Tamoxifen and Raloxifene. A measure of breast density as reported on the entry mammogram report was extracted and categorized according to The American Coll...

PURPOSE We evaluated the performance of the Gail model for a Korean population and developed a Korean breast cancer risk assessment tool (KoBCRAT) based upon equations developed for the Gail model for predicting breast cancer risk. METHODS Using 3,789 sets of cases and controls, risk factors for breast cancer among Koreans were identified. Individual probabilities were projected using Gail's ...

BACKGROUND Strategies for estrogen receptor (ER)-positive breast cancer risk reduction in postmenopausal women require screening of large populations to identify those with potential benefit. We evaluated and attempted to improve the performance of the Breast Cancer Risk Assessment Tool (i.e., the Gail model) for estimating invasive breast cancer risk by receptor status in postmenopausal women....

BACKGROUND The Gail model is widely used for the assessment of risk of invasive breast cancer based on recognized clinical risk factors. In recent years, a substantial number of single-nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified. However, it remains unclear how to effectively integrate clinical and genetic risk factors for risk assessment. METHODS S...

Since last April, when researchers announced evidence that tamoxifen reduces the incidence of breast cancer in high-risk women, doctors have been looking for a systematic way to identify women who qualify as "high risk." To address this need, the National Cancer Institute developed the Breast Cancer Risk Assessment Tool, an interactive computer program released this month as a pilot project. Th...

INTRODUCTION Breast cancer screening programmes are based on various risk models to assess the risk of breast cancer in the general population. The aim of the present study is to predict the efficacy of the Gail model (GM) in the Indian population. We did a retrospective calculation of the Gail score from the hospital records of patients with breast cancer and benign breast disease. MATERIALS...