Previous studies have demonstrated that tonic responses of trigeminal ganglion neurons to maintained whisker deflections are transformed to mainly phasic responses in thalamocortical neurons. The high tonic responsiveness of thalamic reticular neurons suggests that thalamic inhibition may contribute to this suppression of tonic activity. To test this hypothesis we recorded responses of thalamoc...

The contents of GABA, glutamine (Glu) and asparagine (Asp) acids as well as activities of glutamatdecarboxylase (GDK; CF 4.1.1.15) and 4-aminobutirat: 2-oxoglutarataminotransferase (GABA-T: CF 2.6.1.19) in brain cortex, cerebellum, brainstem and hypothalamus under impact of testosterone propionate at a dose of 5 mg/100 g of alive weight of adult albino male rats in spring and autumn were studie...

Gamma-aminobutyric acid (GABA) is a non-protein amino that widely present in organisms. In particular, lactic bacteria (LAB) stand out this regard. The biosynthesis of GABA microorganisms mainly regulated by pH, which usually has the most pronounced effect on fermentation process. Also, production, affects media composition, time, and temperature. important positive functions human health. it k...

Introduction: Fennel is rich in phytoestrogens and is used for estrogen deficiency disorders. Estrogens affect anxiety through neurochemical systems such as GABA-A receptors. In this study the effects of fennel on GABA-A and estrogen receptors in anxiety were investigated. Methods: Adult female Wistar rats weighing (180±20 g) were divided into 8 groups. Groups received saline, fennel (200, ...

although many studies have highlighted the role of gamma-aminobutyric acid (gaba) in the pathophysiology of psychosis, there is no drug-induced animal model in which gaba is manipulated. in this article we propose a hypothetical animal model for psychosis based on the silencing gabaergic system.  the presentation also suggest pre-pulse inhibition test as a preferred approach towards proving thi...

GABA neurotransmission requires a specialized set of proteins to synthesize, transport or respond to GABA. This article reviews results from a genetic strategy in the nematode Caenorhabditis elegans designed to identify the genes responsible for these activities. These studies identified mutations in genes encoding five different proteins: the biosynthetic enzyme for GABA, the vesicular GABA tr...

Alfalfa (Medicago sativa L.) is a widely grown and important forage crop. However, alkali stress detrimental to alfalfa yield nutritional quality. Gamma-aminobutyric acid (GABA) signaling molecule, it participates in responds metabolic regulation related plant growth development stress. In this study, we clarify the effect of spraying seedlings with GABA on tolerance seedlings. We determined th...

The non-classical, but frequently reported behavior of GABA(A) receptor-mediated excitation in mature CNS has long been regarded as a puzzle. We theorize that the function of cortical GABAergic interneurons, which might constitute a subsystem of brain's GABA interneurons, is their ability of switching from inhibitory action to excitatory action depending on the level of spatio-temporal activity...

background preliminary studies revealed that 4-aminobutyric acid (gaba) is a key and major inhibitory neurotransmitter in the brain. evidence from many animal studies and even some clinical studies indicate that gaba is responsible for regulating behavior and also plays an important role in brain functions. previous studies presented glutamic acid decarboxylase as a catalyst for the conversion ...

Background: Hypertension is considered an independent risk factor for cardiovascular mortality in diabetic patients. The present study was designed to determine the role of gamma amino butyric acid B (GABAB) receptor and L-arginine (L-Arg) in GABA-induced vasorelaxation in normal and streptozotocin-induced diabetic rat vessels. Methods: Diabetes was induced by a single i.p. injection of strepto...