UNLABELLED Children and young adults with glioblastoma (GBM) have a median survival rate of only 12 to 15 months, and these GBMs are clinically and biologically distinct from histologically similar cancers in older adults. They are defined by highly specific mutations in the gene encoding the histone H3.3 variant H3F3A , occurring either at or close to key residues marked by methylation for reg...

Abstract AIMS Histone G-34-mutant (H3 G34) gliomas are rare, aggressive infiltrating tumours of the cerebral hemispheres and classified as WHO grade 4 paediatric type diffuse high-grade glioma. They most commonly affect children adolescents. We describe clinicopathological characteristics adult H3 G34-mutant seen at National Hospital for Neurology Neurosurgery over last 10 years. METHOD retrosp...

We look for necessary properties of shareholder-value maximizing corporate boards when shareholders face a trade-off between improving information sharing between the board and management and reducing distortions in decision-making arising out of managerial agency. We draw a distinction between the alignment of preferences of the board with management (which affects information flows) and the a...

Article history: Received 27 October 2007 Received in revised form 18 June 2008 Accepted 18 June 2008 Available online 26 June 2008 This paper investigates the effect of stock market microstructure on managerial compensation schemes. We propose and empirically demonstrate that the sensitivity of chief executive officer's (CEO's) compensations to changes in stockholders' value is higher when the...

During the year prior to management buyout (MBOs) announcements, some target firms exhibit abnormally high discretionary expenses in selling, general and administration, abnormally low discretionary accruals, and realize losses from asset sales. Higher discretionary expenses and losses from asset sales are associated with lower pre-MBO abnormal stock returns, especially for firms with higher in...

ABSTRACT We present new 3-mm continuum and molecular lines observations from the ATOMS survey towards massive protostellar clump, MM1, located in filamentary infrared dark cloud (IRDC), G034.43+00.24 (G34). The observed are tracers of either dense gas (e.g. HCO+/H13CO+ J= 1–0) or outflows CS 2–1). most complete picture to date seven cores MM1 is revealed by dust emission. These found be gravita...

Do corporate inversions cost the US Treasury billions of dollars in tax revenue, justifying legislative responses and even strong-arming corporations from moving their tax domicile abroad? We show that corporate inversions not only do not appear to reduce, but, paradoxically, are even likely to increase tax collections by the US Treasury. JEL classification: M40, G34, H25, F23