نتایج جستجو برای: fxr

تعداد نتایج: 1033  

2013
Barbara Renga Andrea Mencarelli Sabrina Cipriani Claudio D'Amore Adriana Carino Angela Bruno Daniela Francisci Angela Zampella Eleonora Distrutti Stefano Fiorucci

BACKGROUND Toll like receptors (TLRs) sense the intestinal microbiota and regulate the innate immune response. A dysregulation of TLRs function participates into intestinal inflammation. Farnesoid X Receptor (FXR) is a nuclear receptor and bile acid sensor highly expressed in entero-hepatic tissues. FXR regulates lipid metabolism and innate immunity. METHODOLOGY/PRINCIPAL FINDINGS In this stu...

Journal: :Physiological reviews 2009
Philippe Lefebvre Bertrand Cariou Fleur Lien Folkert Kuipers Bart Staels

The incidence of the metabolic syndrome has taken epidemic proportions in the past decades, contributing to an increased risk of cardiovascular disease and diabetes. The metabolic syndrome can be defined as a cluster of cardiovascular disease risk factors including visceral obesity, insulin resistance, dyslipidemia, increased blood pressure, and hypercoagulability. The farnesoid X receptor (FXR...

2015
Xianqin Zhang Toshifumi Osaka Satoshi Tsuneda

BACKGROUND The farnesoid X receptor (FXR), a ligand-activated transcription factor belonging to the adopted orphan receptor, plays an important role in maintaining health of the liver and intestine. In this study, we identified individual bacterial strains that directly modulated the activation of intestinal FXR. METHODS The FXR stimulatory potential of 38 bacterial strains was determined usi...

Journal: :American journal of physiology. Gastrointestinal and liver physiology 2016
Bo Kong Yan Zhu Guodong Li Jessica A Williams Kyle Buckley Ossama Tawfik James P Luyendyk Grace L Guo

Farnesoid X receptor (FXR) belongs to the nuclear receptor superfamily with its endogenous ligands bile acids. Mice with whole body FXR deficiency develop liver tumors spontaneously, but the underlying mechanism is unclear. Moreover, it is unknown whether FXR deficiency in liver alone serves as a tumor initiator or promoter during liver carcinogenesis. This study aims to evaluate the effects of...

2014
Le Zhan Hui-Xin Liu Yaping Fang Bo Kong Yuqi He Xiao-bo Zhong Jianwen Fang Yu-Jui Yvonne Wan Grace L. Guo

BACKGROUND & AIMS Farnesoid X receptor (FXR, NR1H4) is a ligand-activated transcription factor, belonging to the nuclear receptor superfamily. FXR is highly expressed in the liver and is essential in regulating bile acid homeostasis. FXR deficiency is implicated in numerous liver diseases and mice with modulation of FXR have been used as animal models to study liver physiology and pathology. We...

2014
Martijn O. Hoeke Janette Heegsma Mark Hoekstra Han Moshage Klaas Nico Faber

BACKGROUND Farnesoid X receptor/retinoid X receptor-alpha (FXR/RXRα) is the master transcriptional regulator of bile salt synthesis and transport in liver and intestine. FXR is activated by bile acids, RXRα by the vitamin A-derivative 9-cis retinoic acid (9cRA). Remarkably, 9cRA inhibits binding of FXR/RXRα to its response element, an inverted repeat-1 (IR-1). Still, most FXR/RXRα target genes ...

2011
Janne Prawitt Mouaadh Abdelkarim Johanna H.M. Stroeve Iuliana Popescu Helene Duez Vidya R. Velagapudi Julie Dumont Emmanuel Bouchaert Theo H. van Dijk Anthony Lucas Emilie Dorchies Mehdi Daoudi Sophie Lestavel Frank J. Gonzalez Matej Oresic Bertrand Cariou Folkert Kuipers Sandrine Caron Bart Staels

OBJECTIVE Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity. However, the role of FXR in obesity and associated complications, such as dyslipidemia and insulin resistance, has n...

Journal: :Circulation research 2013
Thomas Q de Aguiar Vallim Elizabeth J Tarling Tammy Kim Mete Civelek Ángel Baldán Christine Esau Peter A Edwards

RATIONALE The bile acid receptor farnesoid X receptor (FXR) regulates many aspects of lipid metabolism by variouscomplex and incompletely understood molecular mechanisms. We set out to investigate the molecular mechanisms for FXR-dependent regulation of lipid and lipoprotein metabolism. OBJECTIVE To identify FXR-regulated microRNAs that were subsequently involved in regulating lipid metabolis...

Journal: :European heart journal 2013
Jun Pu Ancai Yuan Peiren Shan Erhe Gao Xiaoliang Wang Yajing Wang Wayne Bond Lau Walter Koch Xin-Liang Ma Ben He

AIMS Emerging evidence indicates that nuclear receptors play a critical regulatory role in cardiovascular physiology/pathology. Recently, farnesoid-X-receptor (FXR), a member of the metabolic nuclear receptor superfamily, has been demonstrated to be expressed in vascular cells, with important roles in vascular physiology/pathology. However, the potential cardiac function of FXR remains unclear....

Journal: :The Journal of biological chemistry 2004
Jane-L Lew Annie Zhao Jinghua Yu Li Huang Nuria De Pedro Fernando Peláez Samuel D Wright Jisong Cui

Farnesoid X receptor (FXR) is a nuclear receptor for bile acids. Ligand activated-FXR regulates transcription of genes to allow feedback control of bile acid synthesis and secretion. There are five major bile acids in humans. We have previously demonstrated that lithocholate acts as an FXR antagonist, and here we show that the other four bile acids, chenodeoxycholate (CDCA), deoxycholate (DCA),...

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