Previous studies have suggested that endogenous protease inhibitors may participate in the mucosal host defense. Antileukoprotease (ALP) is an important protease inhibitor found on various mucosal surfaces, including those of the respiratory and genital tracts. This study reports on the antimicrobial activity of recombinant (r) ALP toward the human fungal pathogens Aspergillus fumigatus and Can...

OBJECTIVES The aim of the present investigation was to study and characterize the effect of voriconazole on the fungicidal activity of amphotericin B. METHODS Four strains of Candida albicans susceptible to voriconazole were exposed to voriconazole and amphotericin B, either alone, simultaneously or sequentially in an in vitro kinetic model. Bolus doses resulting in voriconazole and amphoteri...

Fungicidal activity of widely used imidazole antifungal drugs in topical applications is not so strong in spite of their fungistatic activities against dermatophytes and pathogenic yeasts. In order to improve fungicidal activity of imidazole antifungal agents, a series of novel imidazole derivatives having a hydrophobic substituent derived from isoprenoid were synthesized. The efficacy of these...

This research evaluated the fungistatic and fungicidal activities of red propolis alcoholic extract (RPAE) against different Candida species isolated from chronic periodontitis cases, and compared with chlorhexidine (CHX). Nineteen samples of Candida species (C. albicans [n = 12], C. tropicalis [n = 5] and C. glabrata [n = 2]) isolated from chronic periodontitis cases were analyzed. The fungist...

Background The disinfectants polyhexamethylene biguanide (PHMB) and 1-bromo-3-chloro-5,5-dimethylimidazolidine-2,4-dione (BCDMH) each have limitations. So far, their combined usage has not been examined. In this study, the fungicidal activity of combined disinfectant using PHMB and BCDMH, named PB, against Candida albicans was evaluated. Methods Suspension quantitative fungicidal test and via...

Essential oils (EOs) are plant-derived aroma compounds with a wide range of biological activity, but their actions are slow, and they are typically unstable to light or heat, difficult to extract and so on. To find highly potential fungicides derived from natural EOs, a series of essential oil-based β-methoxyacrylate derivatives have been designed and synthesized. The target compounds have been...

Sea cucumber is presented as potential marine source of antimicrobial compounds. The purpose of this study is to evaluate antifungal effects of sea cucumber, Holothuria leucospilota, extracts on Aspergillus niger and Candida albicans. Methanol and chloroform extracts of the body wall, gonad and intestine of sea cucumber, H. leucospilota, collected from Persian Gulf, were evaluated for their ant...

known as denmert) caused total loss of its fungicidal activity towards Sphaerotheca fuliginea and Monilinia fmctigena. These workers suggested that the co-ordination of the heterocyclic meta-nitrogen atom of buthiobate to a cationic receptor site may be important for its fungicidal activity. The cationic receptor site mentioned would appear to be the Fez+ of the cytochrome P-450 catalysing step...

New diorganotin(IV) complexes of the type Ph2SnL2, Bu2SnL2 and Me2SnL2 of the ligands 2-thioacetic-5-phenyl-1,3,4-oxadiazole (HL1) and benzamidophenylalanine (HL2). Have been synthesized and characterized by physico-chemical techniques such as (elemental analysis, and electrolytic conductance) and spectr...