نتایج جستجو برای: functional toxicity
تعداد نتایج: 697230 فیلتر نتایج به سال:
Amyloids were first identified in association with amyloidoses, human diseases in which proteins and peptides misfold into amyloid fibrils. Subsequent studies have identified an array of functional amyloid fibrils that perform physiological roles in humans. Given the potential for the production of toxic species in amyloid assembly reactions, it is remarkable that cells can produce these functi...
We aimed to identify functional differences between different sections of the thallus Ulva australis and develop tissue-endpoint combinations assess toxicity six metals (i.e., Ag, As, Cd, Cr, Cu, Ni). EC50 values for these in three were obtained multiple endpoints: relative growth rate (RGR), chlorophyll a fluorescence, pigment contents, expression photosynthesis-related gene, rbcL. The respons...
A majority of E. coli proteins when overexpressed inhibit its growth, but the reasons behind overexpression toxicity of proteins remain unknown. Understanding the mechanism of overexpression toxicity is important from evolutionary, biotechnological and possibly clinical perspectives. Here we study sequence and functional features of cytosolic proteins of E. coli associated with overexpression t...
We report on a functional human model to evaluate multi-organ toxicity in a 4-organ system under continuous flow conditions in a serum-free defined medium utilizing a pumpless platform for 14 days. Computer simulations of the platform established flow rates and resultant shear stress within accepted ranges. Viability of the system was demonstrated for 14 days as well as functional activity of c...
The increased presence of chemical contaminants in the environment is an undeniable concern to human health and ecosystems. Historically, by relying heavily upon costly and laborious animal-based toxicity assays, the field of toxicology has often neglected examinations of the cellular and molecular mechanisms of toxicity for the majority of compounds-information that, if available, would streng...
OBJECTIVES/HYPOTHESIS Evaluation of treatment results of orthovoltage X-rays for a selection of previously untreated favorable basal cell carcinomas (BCC) in the head and neck area concerning local control, cosmetic and functional outcome, and toxicity profile. METHODS A consecutive series of patients with primarily treated BCCs who were irradiated by means of orthovoltage X-rays in the Nethe...
BACKGROUND Soluble oligomers of amyloid beta (Abeta) are considered to be one of the major contributing factors to the development of Alzheimer's disease. Most therapeutic development studies have focused on toxicity directly at the synapse. METHODOLOGY/PRINCIPAL FINDINGS Patch clamp studies detailed here have demonstrated that soluble Abeta can also cause functional toxicity, namely it inhib...
The number of older patients with breast cancer has increased due to the aging general population. use a geriatric assessment in this population been advocated many studies and guidelines as it can be used identify high risk populations for early mortality toxicity. Additionally, parameters could predict relevant outcome measures. This systematic review summarizes all available evidence on pred...
Bacterial virulence is a multifaceted trait where the interactions between pathogen and host factors affect the severity and outcome of the infection. Toxin secretion is central to the biology of many bacterial pathogens and is widely accepted as playing a crucial role in disease pathology. To understand the relationship between toxicity and bacterial virulence in greater depth, we studied two ...
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