The present work is aimed at the optimization of nanosuspension of felodipine, a poorly water soluble antihypertensive drug using Full factorial Design. A 3 Full factorial design using Design Expert Version 8.0.7.1was employed to study the effect of the independent variables (diffusing drug concentration and stabilizer concentration) on the dependent variables (particle size, percentage of drug...

Saline waters treatment has become increasingly important for drinking water supply in a greater part of the world. However, some serious limitations had recently been discovered during water treatment, among them the boron problem seems to have a critical meaning. According to the WHO regulations (2011), the boron concentration should be reduced to less than 2.4 mg/L for drinking water. The pu...

solid lipid nanoparticles of atovaquone (atq-sln) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and compritol 888 ato as the lipidmatrices and phospholipon 90h, tween 80, and poloxamer 188 as the surfactants. optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipidmatrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

Solid lipid nanoparticles of atovaquone (ATQ-SLN) were prepared by high shearhomogenization method using tripalmitin, trilaurin, and Compritol 888 ATO as the lipidmatrices and Phospholipon 90H, Tween 80, and poloxamer 188 as the surfactants. Optimizationof the formulations was conducted using 6 sets of 24 full-factorial design based on fourindependent variables that were the number of homogeniz...

full factorial experimental design (23) for the evaluation of slurry ethylene polymerization in the presence of an industrial ticl4/mgcl2 ziegler-natta catalyst was employed. the following parameters were used as independentvariables: al/ti molar ratio, reaction temperature and hydrogen partial pressure. the total polymerization pressure was 9 bar. catalyst activity, mfi (melt flow index) and m...