نتایج جستجو برای: fti
تعداد نتایج: 436 فیلتر نتایج به سال:
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the ras oncogene and are currently in clinical trials. Whereas FTIs inhibit the farnesylation of Ha-Ras, they do not completely inhibit the prenylation of Ki-Ras, the allele most frequently mutated in human cancers. Whereas farnesylation of Ki-Ras is blocked by FTIs, Ki-Ras...
The Federal Aviation Administration (FAA) Telecommunications Infrastructure (FTI) network is an essential component for the day-to-day FAA mission. In this digital era where quick access to information is essential, the FTI network has grown significantly and is used to transport data, services, and information for the National Airspace System (NAS). Whether the follow-on network FTI-2 is compl...
Inflammatory breast carcinoma (IBC) is a highly aggressive form of locally advanced breast cancer that has the ability to invade and block the dermal lymphatics of the skin overlying the breast. In a previous series of studies, our laboratory identified overexpression of RhoC GTPase in >90% of IBCs (K. L. van Golen et al., Clin. Cancer Res., 5: 2511-2519, 1999) and defined RhoC as a mammary onc...
BACKGROUND AND OBJECTIVES High body mass index appears protective in hemodialysis patients, but uncertainty prevails regarding which components of body composition, fat or lean body mass, are primarily associated with survival. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Data between April 2006 and December 2012 were extracted from the Fresenius Medical Care Europe subset of the internation...
Mouse mammary tumor virus-transforming growth factor a (MMTV-TGFa) and MMTV-TGFa/neu transgenic mice develop mammary tumors after a long latency and therefore provide useful model systems for breast cancer with its recognized activation of receptor tyrosine kinase signaling. We used these mice to study the antitumor effect of L-744,832 (FTI), a potent and selective inhibitor of farnesyl-protein...
Muscle mass and strength losses during aging may be associated with declining levels of serum testosterone (T) in men. Few studies have shown a direct relationship between T and muscle mass and strength. Subjects were 262 men, aged 24-90 yr, from the Baltimore Longitudinal Study of Aging, who had T and sex hormone-binding globulin sex hormone-binding globulin (SHBG) measurements, from which the...
Factors that govern host-tumor interaction play a critical role in tumor progression. In previous studies we have shown that oncogenic Ras inhibits the expression of Fas (CD95) and renders Ras-transformed cells resistant to Fas-induced death. We now demonstrate that culture of Ras-transformed cells in the presence of the farnesyltransferase inhibitor (FTI) LB42722 leads to up-regulation of Fas ...
We evaluated the fluorescence polarization immunoassay for total thyroxin (T4) and thyroxin-uptake (T-U) in the Abbott "TDx" Analyzer. Between-assay precision was good when we did once-fortnightly calibration and assayed samples in singleton. Measured T4 concentration was decreased in hemolyzed samples with obvious red coloration and undetectable in severely hemolyzed samples. The T-U assay was...
The distribution of ablation catheter contact force may be important for elucidating the mechanisms of pulmonary vein (PV) reconnection following PV isolation (PVI) for the treatment of paroxysmal atrial fibrillation (PAF). A novel method was developed for the visualisation of tissue contact force on left atrial models derived from segmented MRI data and the approach was tested in 3 patients. T...
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