objective(s) we determined the effect of a high fructose diet either alone or in combination with iranian shallot or garlic extract on cognitive functions, plasma lipid profile, and the intraperitoneal glucose tolerance test (ipgtt). materials and methods following induction of insulin resistance in fructose-fed rats (fru-fed), they were randomly assigned to three subgroups. the first subgroup ...

The relative significance of the pathways for the conversion of d-fructose to d-fructose 1,6-diphosphate via d-fructose 1-phosphate or d-fructose 6-phosphate in Aerobacter aerogenes PRL-R3 was assessed by observing growth patterns of mutants lacking either d-fructose 6-phosphate kinase or d-fructose 1,6-diphosphatase. The mutant lacking d-fructose 6-phosphate kinase grew well on d-fructose or g...

Rowlands DS, Thorburn MS, Thorp RM, Broadbent S, Shi X. Effect of graded fructose coingestion with maltodextrin on exogenous C-fructose and C-glucose oxidation efficiency and high-intensity cycling performance. J Appl Physiol 104: 1709–1719, 2008. First published March 27, 2008; doi:10.1152/japplphysiol.00878.2007.— The ingestion of solutions containing carbohydrates with different intestinal t...

Fructose is specifically taken up by nitrogen-fixing cultures of Anabaena variabilis in the light and lowers the doubling time from 24 to 8 h. The kinetics for both fructose-dependent growth and fructose uptake are exponential. The apparent Km for fructose uptake in N2-fixing cultures is 160 microM for cells not previously exposed to fructose and 50 microM in cells adapted to fructose. Picomola...

Elevated blood fructose concentrations constitute the basis for organ dysfunction in fructose-induced metabolic syndrome. We hypothesized that diet-induced changes in blood fructose concentrations are regulated by ketohexokinase (KHK) and the fructose transporter GLUT5. Portal and systemic fructose concentrations determined by HPLC in wild-type mice fed for 7 days 0% free fructose were <0.07 mM...

The ingestion of solutions containing carbohydrates with different intestinal transport mechanisms (e.g., fructose and glucose) produce greater carbohydrate and water absorption compared with single-carbohydrate solutions. However, the fructose-ingestion rate that results in the most efficient use of exogenous carbohydrate when glucose is ingested below absorption-oxidation saturation rates is ...

The inability of a particular Escherichiu coZi mutant to form colonies on fructose minimal medium is ascribed to the inhibition of growth by glucose 6-phosphate, which accumulates in this strain from a small amount of glucose in the fructose. This explanation requires that fructose metabolism not be initiated by its phosphorylation to fructose 6-phosphate. Experiments in vitro show that fructos...

Although excessive fructose intake is epidemiologically linked with dyslipidemia, obesity, and diabetes, the mechanisms regulating plasma fructose are not well known. Cells transfected with sodium/glucose cotransporter 5 (SGLT5), which is expressed exclusively in the kidney, transport fructose in vitro; however, the physiological role of this transporter in fructose metabolism remains unclear. ...

OBJECTIVE Studies with rats have found that an interaction between fructose and magnesium affects macromineral metabolism; high dietary fructose significantly increased kidney calcification in both male and female rats, particularly when dietary magnesium was low. This study tests the hypothesis that an interaction between dietary fructose and magnesium adversely affects macromineral homeostasi...

The inability of a particular Escherichiu coZi mutant to form colonies on fructose minimal medium is ascribed to the inhibition of growth by glucose 6-phosphate, which accumulates in this strain from a small amount of glucose in the fructose. This explanation requires that fructose metabolism not be initiated by its phosphorylation to fructose 6-phosphate. Experiments in vitro show that fructos...