Friedel-Crafts allylic alkylation of a wide variety of aromatic and heteroaromatic compounds with allylic alcohols catalysed by AuCl(3) (5 mol%) under mild conditions at room temperature was accomplished in good to excellent yields (up to 99%) and regioselectivity.

The treatment of 2-(2-vinylphenyl)acetaldehydes or 3-(2-vinylphenyl)propanals with BF 3 ·Et 2 O results in an intramolecular Prins reaction affording intermediary benzyl carbenium ions, which are then trapped by a variety electron-rich aromatics via Friedel–Crafts alkylation. This cascade Prins/Friedel–Crafts cyclization protocol paves expedient path to medicinally useful 4-aryltetralin-2-ol an...

A gold(I)-catalysed reaction of allylic alcohols and phenols produces chromans regioselectively via a one-pot Friedel-Crafts allylation/intramolecular hydroalkoxylation sequence. The reaction is mild, practical and tolerant of a wide variety of substituents on the phenol.

By employing superacidic fluoroantimonate ionic liquid (IL), [bmim][Sb(2)F(11)], as catalyst, not only thermodynamically-controlled but also kinetically-controlled Friedel-Crafts alkenylations of arenes with alkynes have been realized for the first time.

Beta zeolite supported on silicon carbide, with high thermal conductivity and high mechanical strength, was successfully used as an active and stable catalyst for Friedel-Crafts reactions in a fixed bed configuration.

Friedel–Crafts synthesis of triarylmethanes over 3-methyl-1-sulfonic acid imidazolium tetrachloroaluminate under green conditions:In this work, Friedel–Crafts (FC) alkylation of various arenes with aromatic aldehydes catalyzed by 3-methyl-1-sulfonic acid imidazoliumtetrachloroaluminate {[Msim]AlCl4}, as a green catalyst, to prepare triarylmethanes (TAMs) has been carried out. Some aromatic alde...

Friedel-Crafts acylation of the aryldiazirine with ω-ester-α-acyl halide and successive reduction of the carbonyl group to methylene with triethylsilane and trifluoroacetic acid gave diazirinylated fatty acids. Photoaffinity labeling with the carbene generating precursor, 3-phenyl-3-trifluoromethyldiazirine, has become increasingly important as a photophor. However, the complicated synthesis of...

Chiral N-protected α-amino aryl-ketones are one of the useful precursors used in the synthesis of various biologically active compounds and can be constructed via Friedel-Crafts acylation of N-protected α-amino acids. One of the drawbacks of this reaction is the utilization of toxic, corrosive and moisture-sensitive acylating reagents. In peptide construction via amide bond formation, N-hydroxy...

Friedel–Crafts synthesis of triarylmethanes over 3-methyl-1-sulfonic acid imidazolium tetrachloroaluminate under green conditions:In this work, Friedel–Crafts (FC) alkylation of various arenes with aromatic aldehydes catalyzed by 3-methyl-1-sulfonic acid imidazoliumtetrachloroaluminate {[Msim]AlCl4}, as a green catalyst, to prepare triarylmethanes (TAMs) has been carried out. Some aromatic alde...