نتایج جستجو برای: fragile histidine triad protein
تعداد نتایج: 1262078 فیلتر نتایج به سال:
Fragile histidine triad (FHIT) serves a critical function as a tumor suppressor that inhibits p53 degradation by mouse double minute 2 (MDM2). The functional domains of FHIT involved in tumor inhibition was interpreted. In-silico screening data were employed to construct truncated forms of FHIT to assess their cytotoxic effects on the HT1080 cell line. Full FHIT expression was confirmed by west...
The aim of this study was to investigate Fragile Histidine Triad Gene (FHIT) expression in laryngeal squamous cell carcinoma. The paraffin embedded tissue blocks of 64 laryngeal squamous cell carcinoma specimens were enrolled in the study. FHIT expression was detected by an immunohistochemical method. Rabbit polyclonal antibody was used for immunohistochemical study. FHIT expression was low in ...
A 200-300 kb region of chromosome 3p14.2, including the fragile site locus FRA3B, is homozygously deleted in multiple tumor-derived cell lines. Exon amplification from cosmids covering this deleted region allowed identification of the human FHIT gene, a member of ther histidine triad gene family, which encodes a protein with 69% similarity to an S. pombe enzyme, diadenosine 5', 5''' P1, P4-tetr...
PKC-interacting protein (PKCI), also designated histidine triad nucleotide-binding protein 1, belongs to the histidine triad (HIT) family of proteins. Its structure is highly conserved from bacteria to humans and shares homology with the tumor-suppressor gene fragile histidine triad (FHIT). Although it was originally thought to inhibit PKC, its actual physiologic function is not known. Therefor...
Abbreviations: GBC: Gallbladder Cancer; PCR: Polymerase Chain Reaction; SSCP: Single Strand Conformation Polymorphism; MSI: Microsatellite Instability; CIS: Carcinoma In Situ; AJPBD: Anomalous Junction of Pancreatico Biliary Duct; FHIT: Fragile Histidine Triad; CC: Chronic Cholecystitis; XGC: Xanthogranulomatous Cholecystitis; SAGE: Serial Analysis of Gene Expression; CTGF: Connective Tissue Gr...
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