FR-900520 and FR-900523, novel neutral macrolide immunosuppressants, were isolated from the cultured broth of Streptomyces hygroscopicus subsp. yakushimaensis No. 7238. Their molecular formulae were determined as C43H69NO12 and C42H67NO12, respectively. The compounds suppressed immune response in vitro. IC50 values of FR-900520 and FR-900523 for mouse mixed lymphocyte reaction were 0.55 nM and ...

OBJECTIVE We aimed to describe radiologic signs and time-course of imatinib-associated fluid retention (FR) in patients with gastrointestinal stromal tumor (GIST), and its implications for management. MATERIALS AND METHODS In this Institutional Review Board-approved, retrospective study of 403 patients with GIST treated with imatinib, 15 patients with imaging findings of FR were identified by...

n-methylol dimethyl phosphonopropionamide (mdpa) is one of the most utilized fire resistant (fr) finishes for cotton fabrics, utilized as part of a formulation with trimethylol melamine (tmm) to acquire better crosslinking and enhanced fr properties. the system parameters of the finishing treatment were upgraded for better fr properties and low mechanical loss to the fabric by the response surf...

OBJECTIVE Emergency medical dispatch (EMD) protocols should match response resources with patient needs. We tested a protocol sending only a commercial ambulance, without fire department first responders (FR), to all non-cardiac-arrest EMS calls at a physician-staffed HMO facility. Study objectives were to determine how often FR provided patient care at such facilities and whether EMD implement...

Deep and high resolution radio observations of the Hubble Deep Field and flanking fields have shown the presence of two distant edge-darkened FR I radio galaxies, allowing for the first time an estimate of their high redshift space density. If it is assumed that the space density of FR I radio galaxies at z>1 is similar to that found in the local universe, then the chance of finding two FR I ra...

The Fe(II) and α-ketoglutarate-dependent hydroxylase FrbJ was previously demonstrated to utilize FR-900098 synthesizing a second phosphonate FR-33289. Here we assessed its ability to hydroxylate other possible substrates, generating a library of potential antimalarial compounds. Through a series of bioassays and in vitro experiments, we identified two new antimalarials.