نتایج جستجو برای: foxp3 gene

تعداد نتایج: 1147425  

Journal: :Cell 2007
Tao Zuo Lizhong Wang Carl Morrison Xing Chang Huiming Zhang Yan Liu Yin Wang Xingluo Liu Michael W.Y. Chan Jin-Qing Liu Richard Love Virginia Godfrey Rulong Shen Tim H-M. Huang Tianyu Yang Pan Zheng Yang Liu

The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of the cancers were mammary carcinomas in which the wild-type Foxp3 allele was ina...

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Journal: :Blood 2013
Alicia N McMurchy Jana Gillies Maria Concetta Gizzi Michela Riba Jose Manuel Garcia-Manteiga Davide Cittaro Dejan Lazarevic Sara Di Nunzio Ignazio S Piras Alessandro Bulfone Maria Grazia Roncarolo Elia Stupka Rosa Bacchetta Megan K Levings

The role of forkhead box P3 (FOXP3) is well-established in T-regulatory cells, but the function of transient FOXP3 expression in activated human conventional T (Tconv) cells is unknown. In the present study, we used 2 approaches to determine the role of FOXP3 in human Tconv cells. First, we obtained Tconv clones from a female subject who is hemizygous for a null mutation in FOXP3, allowing the ...

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Journal: :Journal of Immunology 2023

Abstract Regulatory T (T reg) cells developing in the thymus are essential to maintain tolerance and prevent fatal autoimmunity mice humans. Expression of reg lineage-defining transcription factor FoxP3, is critically dependent upon cell receptor (TCR) interleukin-2 (IL-2) signaling. Here, we report that ten-eleven translocation (Tet) enzymes, which DNA demethylases, required early during doubl...

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2017
Elham Beiranvand Saeid Abediankenari Soghra Khani Hamideh Mahmoodzadeh Hosseini Sirous Zeinali Behnoush Beiranvand Mehdi Goudarzi Sima Sadat Seyedjavadi

BACKGROUND Forkhead box protein 3 (FoxP3) is an important factor for development and function of Regulatory T cells (Treg). Studies have found an association between common gene polymorphisms in FoxP3 and some infectious diseases. The aim of this study was to evaluate possible associations between two Single nucleotide polymorphisms (SNPs) in the promoter of the FoxP3 gene to susceptibility to ...

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Journal: :iranian journal of allergy, asthma and immunology 0
fariba raygan department of cardiology, kashan university of medical sciences, kashan, iran mansour sayyah trauma research center, kashan university of medical sciences, kashan, iran mohammad reza janesar qamsari student research center, kashan university of medical sciences, kashan, iran hassan nikoueinejad nephrology and urology research center, baqiyatallah university of medical sciences, tehran, iran mojtaba sehat department of community medicine, kashan university of medical sciences, kashan, iran

there are confirmed beneficiary effects of exercise on atherosclerotic inflammation of ischemia-associated heart diseases. the purpose of this study was to evaluate the effect of aerobic exercise on t-regulatory cell markers of il-35 as well as foxp3 and t-helper2 marker of il-33 in patients with ischemic heart disease (ihd). this research was performed on 44 asymptomatic male patients with isc...

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Journal: : 2021

Objective: We aimed to evaluate the number and function of regulatory T (Treg) cells in peripheral blood prostate tissues patients with histopathologically diagnosed benign hyperplasia (BPH) asymptomatic chronic prostatitis.
 Material Methods: Blood histopathological data 19 (BPH=10, ACP=9) that underwent transurethral resection were evaluated. Treg cell count prostatic tissue flowcytometr...

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2013
Pin Zhang Takashi Maruyama Joanne E. Konkel Brittany Abbatiello Brian Zamarron Zhao-qi Wang WanJun Chen

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme and transcription factor that is involved in inflammatory response, but its role in T cell response remains largely unknown. We show here that PARP-1 regulates the suppressive function of CD4(+)CD25(+)Foxp3(+) regulatory T cells (Tregs). Specifically, Tregs in mice with a null mutation of the PARP-1 gene (PARP-1(-/-)) showed significan...

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Journal: :The Journal of Experimental Medicine 2005
Xing Chang Jian Xin Gao Qi Jiang Jing Wen Nick Seifers Lishan Su Virginia L. Godfrey Tao Zuo Pan Zheng Yang Liu

The Scurfy mutation of the FoxP3 gene (FoxP3(sf)) in the mouse and analogous mutations in human result in lethal autoimmunity. The mutation of FoxP3 in the hematopoietic cells impairs the development of regulatory T cells. In addition, development of the Scurfy disease also may require mutation of the gene in nonhematopoietic cells. The T cell-extrinsic function of FoxP3 has not been characteri...

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2017
Jincheng Zhang Bin Wei Huixian Hu Fanrong Liu Yan Tu Minzhe Zhao Dongmei Wu

The aim of the present study was to analyze the association between the transcription factor forkhead box P3 (FOXP3) and diffuse large B-cell lymphoma (DLBCL), and investigate the effect of microRNA-155 (miR-155) on the generation and development of FOXP3 in DLBCL. The reverse transcription-quantitative polymerase chain reaction (RT-qPCR) technique was used to determine the expression of FOXP3 ...

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2001
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