INTRODUCTION –Short-Axis Propeller EPI (SAP-EPI) has been shown to be very effective in obtaining highresolution, artifact-free DTI data [2]. One challenge with SAP-EPI is that in the presence of head rotation each blade of SAP-EPI data is potentially encoded with a different diffusionencoding direction (i.e. b-matrix) (Fig. 1). Since the diffusion-encoding is ‘imprinted’ on the magnetization, ...

A greater depression of the action potential (AP) of the ventricular epicardium (Epi) versus endocardium (Endo) is readily observed in experimental models of acute ischemia and Brugada syndrome. Endo and Epi differences in transient outward K(+) current and/or ATP-sensitive K(+) channel current are believed to contribute to the differential response. The present study tested the hypothesis that...

18. A. D. Iooe, \Variational analysis of a composite function: a formula for the lower second order epi-derivative," J. 843{865. 21. R. A. Poliquin, \An extension of Attouch's Theorem and its application to second-order epi-diierentiation of convexly composite functions," Trans. Amer. Math. Soc. 18 neighborhood of g ? F(x) and is twice epi-diierentiable with second-order epi-derivative given as...

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related mortality worldwide. Epirubicin (EPI) once acted as a main agent for HCC chemotherapy. However, the dosage-dependent side effects seriously limit its application in clinic. The purpose of this study is to develop an effective nanocarrier to improve the efficacy and overcome the limitations of EPI. In this regard, the EP...

BACKGROUND 3-epi-25-hydroxyvitamin D3 (3-epi-25OHD3) interferes in most liquid chromatography-tandem mass spectrometry (LC-MS/MS) assays for 25-hydroxyvitamin D (25OHD). The clinical significance of this is unclear, with concentrations from undetectable to 230 nmol/L reported. Many studies have quantified 3-epi-25OHD3 based on 25OHD3 calibrators or other indirect methods, and we speculated that...

Abstract Mistletoes have much higher transpiration rates than their hosts. This is the basis for ecological “compatibility hypothesis” host choice. The inability of mistletoes to penetrate a and connect its vascular system competing “immunity hypothesis”. Epi‐parasites would transpire faster mistletoe, which must host. Therefore, epi‐parasites should be able parasitise host's I surveyed epi‐par...

A recent study showed that ergometry increased circulating hematopoietic stem and progenitor cell (CPC) numbers, but reduced hematopoietic colony forming capacity/functionality under normoxia and normobaric hypoxia. Herein we investigated whether an exercise-induced elevated plasma free/bound norepinephrine (NE) concentration could be responsible for directly influencing CPC functionality. Veno...

The pluripotent epiblast (EPI) is the founder tissue of almost all somatic cells. EPI and primitive endoderm (PrE) progenitors arise from the inner cell mass (ICM) of the blastocyst-stage embryo. The EPI lineage is distinctly identified by its expression of pluripotency-associated factors. Many of these factors have been reported to exhibit dynamic fluctuations of expression in embryonic stem c...

High-resolution functional MRI (fMRI) offers unique possibilities for studying human functional neuroanatomy. Although high-resolution fMRI has proven its potential at 7 T, most fMRI studies are still performed at rather low spatial resolution at 3 T. We optimized and compared single-shot two-dimensional echo-planar imaging (EPI) and multishot three-dimensional EPI high-resolution fMRI protocol...

Anthracyclines are effective genotoxic anticancer drugs for treating human malignancies; however, their clinical use is limited by tumour resistance and severe cardiotoxicity (e.g. congestive heart failure). Epirubicin (EPI) is less cardiotoxic compared to other canonical anthracyclines (e.g, doxorubicin). This has been attributed to its unique glucuronidation detoxification pathway. EPI is pri...