The presence of antimicrobial agents in edible tissues of food-producing animals remains a major public health concern. Probabilistic modeling techniques incorporated into a physiologically based pharmacokinetic (PBPK) model were used to predict the amounts of sulfamethazine residues in edible tissues in swine. A PBPK model for sulfamethazine in swine was adapted to include an oral dosing route...

background methamphetamine (ma) is a highly addictive stimulant which has destructive effects. there is also evidence that methamphetamine use in some females, partly is due to their desire to lose weight. the purpose of this study was to determine the association between family flexibility, food preoccupation and body image among crystal abuser women. objectives this study tried to evaluate wh...

Mitochondria integrate metabolic networks for maintaining bioenergetic requirements. Deregulation of mitochondrial metabolic networks can lead to mitochondrial dysfunction, which is a common hallmark of many diseases. Reversible post-translational protein acetylation modifications are emerging as critical regulators of mitochondrial function and form a direct link between metabolism and protein...

Endothermy allows maintenance of a constant internal thermal milieu for optimal physiological functions but results in high energy expenditure and water loss. Since torpor can reduce both expenditure of energy and loss of water and thus reduces food and water requirements, we determined how different food and water regimes affect torpor occurrence and patterns in the dasyurid marsupial Sminthop...

Chronic morphine treatment and naloxone precipitated morphine withdrawal activates stress-related brain circuit and results in significant changes in food intake, body weight gain and energy metabolism. The present study aimed to reveal hypothalamic mechanisms underlying these effects. Adult male rats were made dependent on morphine by subcutaneous implantation of constant release drug pellets....

The correlation between the development of barbital (B)-withdrawal signs and alterations in the metabolism of brain 5-hydroxytryptamine (5-HT) was studied. Barbital (B)-dependent rats were prepared by the B-Admixed Food method (DAF method). The B-dependent rats were grouped according to the following 5 states: G-I, B-dependent state; G-II, B-withdrawn state; G-III, cross-administration of nitra...

BACKGROUND The aim of this study was to test a weight loss program for young people based on an addiction treatment approach. METHODS A pilot study (n=43) was conducted of a 20-week child/adolescent obesity intervention based on an addiction treatment model (staged, incremental withdrawal from problem foods, snacking/grazing, and excessive amounts at meals) and implemented by a server-integra...

Violative drug residues in animal-derived foods are a global food safety concern. The use of a fixed main metabolite to parent drug (M/D) ratio determined in healthy animals to establish drug tolerances and withdrawal times in diseased animals results in frequent residue violations in food-producing animals. We created a general physiologically based pharmacokinetic model for representative dru...

Background Eosinophilic esophagitis (EoE) is an immune-mediated disease of the esophagus characterized by symptoms related to esophageal disfunction and histollogically by an eosinophil-predominat inflammation. Multiple therapies have been suggested to be helpful in EoE including endoscopic dilation, medical therapy and withdrawal dietary but, the election of what food should be excluded is ver...