Introduction: High levels of homocysteine (Hcy) might accelerate dopaminergic cell death through oxidative stress and excitotoxicity. Folate plays an important role in the control of plasma levels of Hcy. In this study, effect of supplementation with folic acid on the 6-hydroxydopamine (6-OHDA)-induced Parkinsonism in rat and also serum level of Hcy was investigated. Methods: Rats were fed ...

introduction: elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin b12 and folate insufficiency. folate and vitamin b12 have a protective effect on cardiovascular disease. this effect may be partly explained by mechanisms independent of homocysteine. this survey is the first population based study to evaluate the plasma to...

the purpose of this study was to investigate the effects of short-term creatine monohydrate (cr) and folic acid (fa) supplementation on homocysteine (hcy) levels in young active males. eighteen young male soccer players (21.11±2.02 years, vo2max 56.51±2.31, hcy 13.45±0.59) volunteered to participate in this study. they were randomly divided into creatine monohydrate (n=6), folic acid (n=6) and ...

hydrogels, due to their unique potentials such as high-water content and hydrophilicity are interest for the controlled release of drug molecules. the present study aims to create a controlled-release system through the preparation and characterization of hydrogels based on ph-sensitive polymers such as poly (acrylic acid). poly (acrylic acid), p(aa), hydrogel has been synthesized by radical po...

background: the human immunodeficiency virus (hiv) is one of the most life- threatening human infections. the advent of highly active antiretroviral therapy (haart) has dramatically changed the course of hiv infection and patients' quality of life. in addition to the benefits, haart can have numerous side effects and toxicities. therefore, we aimed to assess the impact of short-term vitamins tr...