AIM The study objective was to evaluate the pathological changes of the placenta in foetal death and foetal growth restriction and to find correlation of the findings with clinical causes. SETTING AND DESIGN Prospective study at a tertiary care hospital. MATERIAL AND METHODS Gross and histopathological examinations of the placentae were carried out in pregnancies with foetal demise (IUD) an...

We have previously reported that foetal and adult fibroblasts display distinctive migratory phenotypes when cultured on three-dimensional collagen gels. Both skin and tumour-derived fibroblasts from a significant proportion of patients with breast cancer were subsequently observed to display foetal-like migratory behaviour. In the accompanying paper concerned with the biochemical basis of these...

The acid-base balance in 307 Chinese patients in labour was studied in Tsan Yuk Hospital, Hong Kong over a 15-month period. Fifty-six of these were normal cases, 200 cases exhibited clinical signs of foetal distress and the other fifty-one were high risk cases. The results showed that cases of clinical foetal distress had a significantly lower foetal pH than that in the normal control group. Of...

Foetal well-being during labour is of utmost importance. One of the ways to attempt to assess foetal wellbeing is by recording foetal heart rate (FHR). Loss of variability and deceleration patterns are known to be associated with foetal distress. Decelerations and foetal bradycardia have been described after any type of effective labour analgesia. This review addresses the questions if certain ...

Alternative splicing (AS) drives determinative changes during mouse heart development. Recent high-throughput technological advancements have facilitated genome-wide AS, while its analysis in human foetal heart transition to the adult stage has not been reported. Here, we present a high-resolution global analysis of AS transitions between human foetal and adult hearts. RNA-sequencing data showe...

Diabetes in pregnancy starts affecting the foetus even in the pre-conception period. The complications encountered in third trimester are foetal macrosomia and intrauterine foetal demise; birth of a macrosomic baby further leads to shoulder dystocia, birth trauma, brachial plexus injury. Additionally, pregnancies with overt/pregestational diabetes may be complicated with foetal growth restricti...

Environmental factors are implicated in increased incidence of human testicular germ-cell cancer (TGCC). TGCC has foetal origins and may be one component of a testicular dysgenesis syndrome (TDS). Certain phthalates induce TDS in rats, including effects on foetal germ cells (GC). As humans are widely exposed to phthalates, study of the effects of phthalates on foetal rat GC could provide an ins...

BACKGROUND/OBJECTIVE An adequate supply of long-chain polyunsaturated fatty acids (LC PUFA) promotes foetal health and development, whereas generally, trans fatty acids (tFA) are considered to negatively interfere with LC PUFA metabolism. Nevertheless, to date, limited data concerning separate trans C18:1, such as t9 and t11, are available for maternal and foetal blood. Therefore, in this study...

process. 1. The Foetal Electrocardiogram: The examination of the FECG by the traditional methods of cardiology have proved very disappointing and unrewarding. If, however, the FECG is merely used as a means of recording the beat-to-beat interval of the foetal heart, statistical evaluation of this information can yield a valuable prognostic index. 2. The Foetal Ballistocardiogram: The purpose of...