The Malignant Neuroleptic Syndrome (M. N. S.) as a relatively uncommon but potentially lethal complication of neuro-leptic drug treatment was first described in the French literature by Delay el al. (1960), and several cases of so called 'Malig-nant Hyperthermia' in relation to neuro-leptic drug intake were described. It is only in the last few years that this syndrome has received some attenti...

A case of prolonged and refractory neuroleptic malignant syndrome was treated successfully with electroconvulsive therapy. Neuroleptic malignant syndrome and its treatment are reviewed.

When fever occurs in a patient treated with a neuroleptic, the diagnosis of a neuroleptic malignant syndrome is difficult to differentiate to that of an infectious event. Among inflammation biomarkers of inflammation, serum procalcitonin levels increase both quickly and specifically during a bacterial infection. We report the first case of a neuroleptic malignant syndrome associated with a sign...

CONTEXT A case of neuroleptic malignant syndrome and acute respiratory distress syndrome is presented and discussed with emphasis on the role of muscle relaxation, creatine kinase, and respiratory function tests. CASE REPORT A 41-year-old man presented right otalgia and peripheral facial paralysis. A computed tomography scan of the skull showed a hyperdense area, 2 cm in diameter, in the path...

Few conditions have attracted such widespread attention among both neurologists and psychiatrists in recent years as the neuroleptic malignant syndrome. First described in 1960 by French clinicians in a study of haloperidoll and subsequently named the "syndrome malin des neuro-leptiques",2 this nomenclature suffered in translation to the neuroleptic malignant syndrome; this term has endured, in...

The neuroleptic malignant syndrome and the serotonin syndrome share many clinical features and may exist on a spectrum of the same disorder. The neuroleptic malignant syndrome, however, is an idiosyncratic drug reaction, whereas the serotonin syndrome is an effect of drug toxicity. Both syndromes present with varying degrees of mental status changes and autonomic instability. In general, patien...

INTRODUCTION Neuroleptic malignant syndrome is rare, but potentially fatal idiosyncratic reaction to antipsychotic medications. It is sometimes difficult to diagnose some clinical cases as neuroleptic malignant syndrome and differentiate it from the acute viral encephalitis. CASE REPORT We reported a patient diagnosed with acute psychotic reaction which appeared for the first time. The treatm...

A sensitive radioimmunoassay was developed to determine the steady-state, fixed-dose pharmacokinetic profile of fluphenazine decanoate in nine outpatients. To see if neuroleptic blood levels measured by this assay correlated with a clinical event, we performed a cross-sectional study of fluphenazine blood levels in 11 patients with and 17 patients without tardive dyskinesia. The results do not ...