نتایج جستجو برای: fluoroquinolone

تعداد نتایج: 3959  

2014
Elena López Arnau Domenech María-José Ferrándiz Maria João Frias Carmen Ardanuy Mario Ramirez Ernesto García Josefina Liñares Adela G. de la Campa

Antibiotic resistance in Streptococcus pneumoniae has increased worldwide by the spread of a few clones. Fluoroquinolone resistance occurs mainly by alteration of their intracellular targets, the type II DNA topoisomerases, which is acquired either by point mutation or by recombination. Increase in fluoroquinolone-resistance may depend on the balance between antibiotic consumption and the cost ...

متن کامل
Journal: :Journal of immunology 1998
Y Tokura N Seo H Yagi F Furukawa M Takigawa

Fluoroquinolone antibacterial agents are well known to elicit photosensitivity as an adverse effect, and their cross-reactivity has been clinically documented. The photoallergenicity of fluoroquinolones is mainly derived from their photohaptenic moiety, and photomodification of skin epidermal cells with fluoroquinolones is thought to be an initial step for this photoallergy. Here we have explor...

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Journal: :Proceedings of the National Academy of Sciences of the United States of America 2016
Tim R Blower Benjamin H Williamson Robert J Kerns James M Berger

Mycobacterium tuberculosis (Mtb) infects one-third of the world's population and in 2013 accounted for 1.5 million deaths. Fluoroquinolone antibacterials, which target DNA gyrase, are critical agents used to halt the progression from multidrug-resistant tuberculosis to extensively resistant disease; however, fluoroquinolone resistance is emerging and new ways to bypass resistance are required. ...

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2017
Kate E Dingle Xavier Didelot T Phuong Quan David W Eyre Nicole Stoesser Tanya Golubchik Rosalind M Harding Daniel J Wilson David Griffiths Alison Vaughan John M Finney David H Wyllie Sarah J Oakley Warren N Fawley Jane Freeman Kirsti Morris Jessica Martin Philip Howard Sherwood Gorbach Ellie J C Goldstein Diane M Citron Susan Hopkins Russell Hope Alan P Johnson Mark H Wilcox Timothy E A Peto A Sarah Walker Derrick W Crook Carlos Del Ojo Elias Charles Crichton Vasiliki Kostiou Adam Giess Jim Davies

BACKGROUND The control of Clostridium difficile infections is an international clinical challenge. The incidence of C difficile in England declined by roughly 80% after 2006, following the implementation of national control policies; we tested two hypotheses to investigate their role in this decline. First, if C difficile infection declines in England were driven by reductions in use of particu...

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Journal: :Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2015
M A M Yassien M A Elfaky

A spontaneous fluoroquinolone-resistant mutant (STM1) was isolated from its parent Salmonella enterica serovar Typhi (S. Typhi) clinical isolate. Unlike its parent isolate, this mutant has selective resistance to fluoroquinolones without any change in its sensitivity to various other antibiotics. DNA gyrase assays revealed that the fluoroquinolone resistance phenotype of the STM1 mutant did not...

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1998
Yoshiki Tokura Naohiro Seo Hiroaki Yagi Fukumi Furukawa Masahiro Takigawa

Fluoroquinolone antibacterial agents are well known to elicit photosensitivity as an adverse effect, and their cross-reactivity has been clinically documented. The photoallergenicity of fluoroquinolones is mainly derived from their photohaptenic moiety, and photomodification of skin epidermal cells with fluoroquinolones is thought to be an initial step for this photoallergy. Here we have explor...

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2016
Hyun Woo Lee Jung Kyu Lee Eunyoung Kim Jae-Joon Yim Chang-Hoon Lee

BACKGROUND Fluoroquinolone is recommended as a pivotal antituberculous agent for treating multi-drug-resistant pulmonary tuberculosis. However, its effectiveness as first-line treatment remains controversial. The present study was conducted to validate the fluoroquinolone-containing regimen for drug-sensitive pulmonary tuberculosis. METHODS We searched MEDLINE, EMBASE, and the Cochrane Centra...

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2014
Ling-Cong KONG Duo GAO Yun-Hang GAO Shu-Ming LIU Hong-Xia MA

The minimum inhibitory concentrations (MICs), mutation prevention concentrations (MPCs) and contribution of quinolone resistance-determining region (QRDR) mutations to fluoroquinolone (ciprofloxacin, enrofloxacin and orbifloxacin) susceptibility in 23 Pasteurella multocida (Pm) isolates were investigated. Fluoroquinolone-susceptible isolates (MICs ≤0.25 µg/ml, 9 isolates) had no QRDR mutations,...

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Journal: :Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007
John J Carothers Michael G Bruce Thomas W Hennessy Michael Bensler Julie M Morris Alisa L Reasonover Debby A Hurlburt Alan J Parkinson John M Coleman Brian J McMahon

The relationship between prior fluoroquinolone use and levofloxacin resistance in Helicobacter pylori infection is unknown. Among 125 enrolled patients, 8.8% had H. pylori isolates that were resistant to levofloxacin. Levofloxacin resistance was associated with any prior fluoroquinolone use over the previous 10 years and with the total number of fluoroquinolone courses prescribed (P<.001).

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Journal: :Antimicrobial agents and chemotherapy 2008
Michael J Pultz Michelle M Nerandzic Usha Stiefel Curtis J Donskey

After mice received orogastric administration of a fluoroquinolone-resistant Klebsiella pneumoniae strain, subcutaneous treatment with ciprofloxacin, levofloxacin, and moxifloxacin promoted persistent low-density colonization in 10% to 40% of the mice, whereas treatment with clindamycin consistently promoted high-density colonization. No emergence of fluoroquinolone-resistant gram-negative baci...

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