Two cases are presented which exhibit classical dental fluorosis in the permanent dentition which is most logically explained by the excessive intake of fluoride. The cases emphasize the narrow therapeutic range of systemic fluorides in children and the need for analyzing samples of local drinking water before caries-preventive fluoride therapy can be initiated. The potential for induction of f...

AIM To assess the effect of combined use of chlorhexidine and fluoride varnish on the remineralization of incipient carious lesions in young children. MATERIALS AND METHODS Twenty caries-active children (80 lesions) were randomly divided into four groups and subjected to initial examination. Caries status was assessed visually and with the aid of DIAGNOdent. Baseline enamel biopsies were obta...

The paper discusses a possible new concept of the role of fluoride and its mechanism of action in caries prevention. In the past fluoride inhibition of caries was ascribed to reduced solubility due to incorporation of fluoride (F) into the enamel minerals (firmly bound fluoride or fluorapatite). Based on the new findings, it appears that fluoride, either released into or present in the fluid ph...

s of papers accepted for XXVIth ISFR Conference Fluoride 2005;38(3):242-243 Abstract number: 32 XXVIth ISFR Conferencenumber: 32 XXVIth ISFR Conference APPENDIX 3. Kenya study abstract [Neurath 2005a] CN 12/11/2015 1 242 Abstracts of papers accepted for XXVIth ISFR Conference FLUORIDE THERAPY FOR OSTEOPOROSIS REVISITED Abstract number: Present in only trace amounts in soft tissues of the body, ...

There are now a number of different approaches to preventing dental caries available to the clinician. Caries preventive methods are frequently used in combination. This paper reviews the potential effectiveness of combinations of preventive methods. Three groups of studies are reviewed; combinations of fluoride procedures; fluoride and fissure sealants; chlorhexidine and other agents. The revi...

Vertébral osteoporosis is characterized by a prédominant atrophy of spongy bone inducing non-traumatic vertébral fractures. Because a low bone mass is the major déterminant of fracture risk, the idéal therapy for established vertébral osteoporosis should increase trabecular bone mass substantially, thereby decreasing the risk of new crush fractures. This idéal treatment should also be capable o...

BACKGROUND Voriconazole is a triazole antifungal medication used for prophylaxis or to treat invasive fungal infections. Inflammation of the periosteum resulting in skeletal pain, known as periostitis, is a reported side effect of long-term voriconazole therapy. The trifluorinated molecular structure of voriconazole suggests a possible link between excess fluoride and periostitis, as elevated b...

We have compared the renal excretion of fluoride in a variety of patients with chronic renal failure maintained with and without protein restriction before and during regular dialysis treatment and after transplantation. The patients tended to continue to excrete normal dietary loads of fluoride quite well until renal function was seriously reduced. From a regression of function on excretion th...

BACKGROUND & OBJECTIVES Chronic fluoride intoxication through drinking water is a serious health problem. Patients with diabetes are known to have impaired renal function and elimination of fluoride from the body is mainly done through kidney. Fluoride toxicity in diabetes patients may aggravate complications. In this study, the influence of fluoride was assessed on streptozotocin (STZ) induced...

Knowledge of levels of fluoride ingestion and excretion is important in planning optimum fluoride therapy for young children. In previous literature, it has been assumed that only about one-third of ingested fluoride is excreted in young children. The aims of the present study were (a) to measure total fluoride intake, urinary fluoride excretion and fluoride balance, and (b) to investigate the ...