PURPOSE To investigate if anatomical characteristics of eyes undergoing ranibizumab therapy were predictive of best-corrected visual acuity (BCVA) outcomes over 2 years. METHODS Post hoc analyses of patients with age-related macular degeneration from PIER studies, defined by fundus fluorescein angiography, quantitative optical coherence tomography (OCT), and qualitative OCT, were performed to...

Caption: Pyramidal neurons, light micrograph with Nissl staining. This sample, from a human brain, shows two pyramidal neurons. Pyramidal neurons (nerve cells) have a triangular cell body with dendrites leading from two of their corners and one long axon (bottom) extending from the other. The cell nuclei (round, dark) are visible here. Information from the dendrites is processed by the cell bod...

Since MacLean and Maumenee (I960) first examined the fundus of patients with slit-lamp and indirect ophthalmoscopy after the injection of 5 per cent. intravenous sodium fluorescein, and Novotny and Alvis (I96I) made the first successful photographs of the passage of dye through the retinal, vessels with a modified fundus camera, fluorescein fundus angiography (FFA) has come to occupy a unique p...

PURPOSE To report a case of acute quinine poisoning, document acute and chronic macular changes with optical coherence tomography imaging and fluorescein angiography (FA), and to review the literature on ocular toxicity of quinine. METHODS A 32-year-old white female presented to our Emergency Department after ingesting over 7.5 g of quinine. She underwent a complete ophthalmologic examination...

Since MacLean and Maumenee (I960) first examined the fundus of patients with slit-lamp and indirect ophthalmoscopy after the injection of 5 per cent. intravenous sodium fluorescein, and Novotny and Alvis (I96I) made the first successful photographs of the passage of dye through the retinal, vessels with a modified fundus camera, fluorescein fundus angiography (FFA) has come to occupy a unique p...

OBJECTIVE To describe the autofluorescence (AF) characteristics of choroidal neovascularization (CNV) in patients with age-related macular degeneration. METHODS Autofluorescence images of 65 consecutive eyes with CNV at various stages of evolution were analyzed. Twenty images were of recent-onset CNV (group 1), 8 were of eyes 1 to 6 months after CNV diagnosis (group 2), and 37 were late-stage...

The hereditary choroidal dystrophies are divided into (1) geographic choroidal dystrophies (central areolar, peripapillary, generalised), (2) gyrate atrophy, and (3) choroideremia. Each of these disorders is discussed with regard to mode of inheritance, age of onset, symptoms, fundus appearance, and visual function testing. A typical case history of each disorder is presented together with fluo...