Nanoparticles (NPs) are applied in a wide range of processes, and their use continues to increase. Fluidization is one of the best techniques available to disperse and process NPs. NPs cannot be fluidized individually; they fluidize as very porous agglomerates. The objective of this article is to review the developments in nanopowder fluidization. Often, it is needed to apply an assistance meth...

Fluidized bed has many advantages such as high heat and mass transfer rates, temperature homogeneity and good mixing property. However, conventional fluidized bed has some limitations; operation at high gas velocity leads to slugging and there exists minimum particle size for the uniform fluidization. Recently, a rotating fluidized bed (RFB) has attracted special interest, since it has a possib...

Here, we statistically identified the critical factor of the granulation rate during the fluidized bed granulation process. Lactose was selected as the excipient and was granulated with several binders, including hydroxypropyl cellulose, hydroxypropyl methyl cellulose, and polyvinylpyrrolidone. The viscosity, density, and surface tension of the binder solution, contact angle, and the work done ...

A multi-scale three-stage population balance model (TSPBM) was developed in combination with the multivariate projection models to obtain the unknown kernel constants in population balance model (PBM), considering the batch and multi-stage characteristics of the top-spray fluidized bed granulation process. Partial least square (PLS) regression is adopted as the particle-scale modeling method in...