نتایج جستجو برای: fluctuation hypothesis fh
تعداد نتایج: 247227 فیلتر نتایج به سال:
In an attempt to evade annihilation by the vertebrate complement system, many microbes capture factor H (FH), the key soluble complement-regulating protein in human plasma. However, FH is normally an active complement suppressor exclusively on self-surfaces and this selective action of FH is pivotal to self versus non-self discrimination by the complement system. We investigated whether the bac...
The serum proteins factor H (FH), consisting of 20 complement control protein modules (CCPs), and its splice product FH-like protein 1 (FHL-1; consisting of CCPs 1-7) are major regulators of the alternative pathway (AP) of complement activation. The engineered version of FH, miniFH, contains only the N- and C-terminal portions of FH linked by an optimized peptide and shows ∼ 10-fold higher ex v...
BACKGROUND Familial hypercholesterolemia (FH) is a prevalent hereditary disease associated with increased atherosclerosis and calcific aortic valve disease (CAVD). However, in both FH and non-FH individuals, the role of hypercholesterolemia in the development of CAVD is poorly understood. This study used Rapacz FH (RFH) swine, an established model of human FH, to investigate the role of hyperch...
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is caused by mutations in the Krebs cycle enzyme fumarate hydratase (FH). It has been proposed that "pseudohypoxic" stabilization of hypoxia-inducible factor-α (HIF-α) by fumarate accumulation contributes to tumorigenesis in HLRCC. We hypothesized that an additional direct consequence of FH deficiency is the establishment of a biosynthe...
Ischemic stroke and coronary heart disease (CHD) share common mechanisms through blood circulation, but their relationships with cholesterol levels are different. In the case of CHD, “the lower, the better” hypothesis with regards to cholesterol has prevailed so far in clinical fields, setting upper limits of cholesterol levels and advising maintenance of the levels below the limits. However, t...
Batch experiments were conducted to study the adsorption behaviors of lead ion (Pb2+) onto ferrihydrites prepared using three different procedures which were characterized by textural analysis (BET). The adsorption removal of Pb2+ by the three ferrihydrites (called FH-1, FH-2 and FH-3, respectively) were compared, and FH-3 shows fast adsorption kinetics as well as hig...
Hypercholesterolemia has been suggested to have direct negative effects on myocardial function due to increased reactive oxygen species (ROS) generation and increased myocyte death. Mitochondrial permeability transition (MPT) is a significant mediator of cell death, which is enhanced by ROS generation and attenuated by exercise training. The purpose of this study was to investigate the effect o...
batch experiments were conducted to study the adsorption behaviors of lead ion (pb2+) onto ferrihydrites prepared using three different procedures which were characterized by textural analysis (bet). the adsorption removal of pb2+ by the three ferrihydrites (called fh-1, fh-2 and fh-3, respectively) were compared, and fh-3 shows fast adsorption kinetics as well as high adsorption capacities, t...
Heterozygous familial hypercholesterolemia (FH) is associated with a moderate decrease of plasma apoA-I and HDL-cholesterol levels. The aim of the study was to test the hypothesis that these abnormalities were related to an increase of HDL-apoA-I fractional catabolic rate (FCR). We performed a 14-h infusion of [5,5,5-(2)H(3)]leucine in seven control subjects and seven heterozygous FH patients (...
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