An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

depending on the moisture contents, the soil behavior is revealed as solid, semisolid, plastic and liquid states. liquid limit is an important property of fine-grained soils and casagrande and cone penetrometer are two different methods employed for the determination of liquid limit of the soil. in forest environment, the casagrande method is the classic method for liquid limit determination, b...

i. Low overhead automated and precise detection of concurrency bugs at scale. ii. Using low overhead bug detection tools to guide speculative program transformations for performance. iii. Techniques to reduce the concurrency required to reproduce a bug using partial program restart/replay. iv. Techniques to provide reproducible execution of floating point programs. v. Techniques for tuning the ...

Floating point units form an important component of many reconfigurable computing applications. The creation of floating point units under a collection of area, latency, and throughput constraints is an important consideration for system designers. Given the range of possible tradeoffs, most commercial or academic floating point libraries for FPGAs provide a small fraction of possible floating ...

in the current study, floating dosage form containing acyclovir was developed to increase its oral bioavailability. effervescent floating tablets containing 200 mg acyclovir were prepared by direct compression method with three different rate controlling polymers including hydroxypropyl methylcellulose k4m, carbapol 934, and polyvinylpyrrolidone. optimized formulation showed good floating prope...

The second messenger cyclic adenosine monophosphate (cAMP) plays a pivotal role in axonal growth and guidance, but its downstream mechanisms remain elusive. In this study, we report that type II protein kinase A (PKA) is highly enriched in growth cone filopodia, and this spatial localization enables the coupling of cAMP signaling to its specific effectors to regulate guidance responses. Disrupt...