in the current study, floating dosage form containing acyclovir was developed to increase its oral bioavailability. effervescent floating tablets containing 200 mg acyclovir were prepared by direct compression method with three different rate controlling polymers including hydroxypropyl methylcellulose k4m, carbapol 934, and polyvinylpyrrolidone. optimized formulation showed good floating prope...

This thesis completion works it out to deepen into diverse modeling techniques for Point Absorbers. A combined frequency-time domain model is conceived, designed and developed in Matlab with FoRtran as a base., leading to obtain physical variables of primary importance, namely position, velocity and power to Energy net balance relationships of absorption. Integration of different degrees of fre...

An oral sustained-release floating tablet formulation of metformin HCl was designed and developed. Effervescence and swelling properties were attributed on the developed tablets by sodium bicarbonate and HPMC-PEO polymer combination, respectively. Tablet composition was optimized by response surface methodology (RSM). Seventeen (17) trial formulations were analyzed according to Box-Behnken desi...

the purpose of this research was to prepare a floating matrix tablet containing domperidone as a model drug. polyethylene oxide (peo) and hydroxypropyl methylcellulose (hpmc) were evaluated for matrix-forming properties. a simplex lattice design was applied to systemically optimize the drug release profile. the amounts of peo wsr 303, hpmc k15m and sodium bicarbonate were selected as independen...

This thesis completion works it out to deepen into diverse modeling techniques for Point Absorbers. A combined frequency-time domain model is conceived, designed and developed in Matlab with Fortran as a base, leading to obtain physical variables of primary importance, namely position, velocity and power to energy net balance relationships of absorption. Integration of different degrees of free...

this paper highlights the effect of silt content on cone tip resistance in loose silty sand. in this study, twenty-seven cone penetration tests are performed in saturated silty sand samples with several different silt contents ranging from 10 to 50 percent. the samples are consolidated at three overburden stresses including 100, 200 and 300 kpa. it is shown that, as the silt content increases, ...

This paper presents a high speed binary floating point multiplier based on Hybrid Method. To improve speed multiplication of mantissa is done using Hybrid method replacing existing multipliers like Carry Save Multiplier, Dadda Multiplier and Modified Booth Multiplier. Hybrid method is a combination of Dadda Multiplier and Modified Radix-8 Booth Multiplier. The design achieves high speed with ma...

A fuzzy sliding mode control method is proposed to eliminate the interference that suspended floating objects suffered in the on-ground low-gravity simulation system. Due to the change of sling swing-angle that caused by the external interference is weak, the time integral of the sling swing-angle is taken as tracking errors. Meanwhile the values of angle and the angle differential should be co...

Human thyroid epithelial cells were isolated from surgically resected human thyroid gland with collagenase and cultured for one week under EGF-supplemented conditions to allow them to proliferate. Then the cells were transferred to the following three-dimensional culture systems. One was a culture of isolated cells between floating double layers of collagen gel, designated the "floating sandwic...