The conventional view of a protein structure as static provides only a limited picture. There is increasing evidence that protein dynamics are often vital to protein function including interaction with partners such as other proteins, nucleic acids, and small molecules. Considering flexibility is also important in applications such as computational protein docking and protein design. While resi...

Nowadays, manufacturing organisations face increasing pressures from the frequent change in product type, continuous demand fluctuation and unexpected change in customer requirements. In order to survive in the turbulent environment, manufacturing organisations must become flexible and responsive to these dynamic changes in the business environment. This paper presents a hierarchical agent bidd...

The coupling of structural fluctuation and the dynamics of associated water molecules of biological macromolecules is vital for various biological activities. Although a number of molecular dynamics (MD) studies on proteins/DNA predicted the importance of such coupling, experimental evidence of variation of hydration dynamics with controlled structural fluctuation even in model macromolecule is...

This study aimed to explore non-verbal executive processes in simultaneous interpreters. Simultaneous interpreters, bilinguals without any training in simultaneous interpreting, and control monolinguals performed the Wisconsin card sorting task (WCST; Experiment 1) and the Simon task (Experiment 2). Performance on WCST was thought to index cognitive flexibility while Simon task performance was ...

2014 Dynamic light scattering measurements on oriented samples of dilute lyotropic smectics have been performed. The hydrodynamics of two-component smectics A is applied to describe the fluctuation spectrum in our multicomponent samples. The experimentally relevant hydrodynamic mode is the undulation/baroclinic mode, which arises from the coupling between concentration and layer displacement fl...

Mean macromolecular dynamics was quantified in vivo by neutron scattering in psychrophile, mesophile, thermophile and hyperthermophile bacteria. Root mean square atomic fluctuation amplitudes determining macromolecular flexibility were found to be similar for each organism at its physiological temperature ( approximately 1 A in the 0.1 ns timescale). Effective force constants determining the me...

The kink-turn (K-turn) motif is recognized and bound by a family of proteins that act as nucleation factors for ribonucleoparticle assembly. The binding of various proteins to a conserved RNA structural motif known as the K-turn has been shown to be an important component of regulation in the ribosome, in the spliceosome, and in RNA modification. 15.5K is a prototypical example of a K-turn bind...

X iv :0 80 2. 00 29 v1 [ qbi o. B M ] 3 1 Ja n 20 08 Structural Fluctuations of Microtubule Binding Site of KIF1A in Different Nucleotide States Ryo Kanada,1, 2, ∗ Fumiko Takagi,3, 2 and Macoto Kikuchi2, 3, 4, 5 1Department of biophysics, Kyoto University, Kyoto 606-8502, Japan 2Cybermedia Center, Osaka University, Toyonaka 560-0043, Japan 3Formation of Soft Nanomachines, Core Research for Evol...

Reminding children to think about alternatives is a strategy adults often use to promote children's cognitive flexibility, as well as children's engagement in and enjoyment of the task. The current study investigated whether the impacts of reminders on kindergarten children's cognitive flexibility, intrinsic motivation, and mood are moderated by who provides the reminders. Eighty-three healthy ...