We conducted a prospective randomized trial to evaluate the ability of the interleukin-3/granulocyte-macrophage colony-stimulating factor (GM-CSF) fusion protein, PIXY321, to ameliorate cumulative thrombocytopenia after multiple cycles of 5-fluorouracil, leucovorin, doxorubicin, cyclophosphamide (FLAC) chemotherapy compared with GM-CSF in patients with advanced breast cancer. Fifty-three patien...

In order to study the stability control mechanism of deep soft rock roadway and active support technology anchor-grouting flexible bolt, this paper takes west wing transportation Yuandian No. 2 Coal Mine Huaibei Mining Co., Ltd., Huaibei, China as research background. By analyzing occurrence conditions failure characteristics surrounding structural mechanical properties combined with elastic–pl...

Abstract In current research, a novel geometrical technique is introduced to estimate the length ( L ) of sliding arc by considering slip surface entry point distance d e ). Morgenstern-Price limiting equilibrium and strength reduction methods are selected within framework SLOPE/W FLAC 3D softwares respectively, study mechanism stability-effecting factor for loose rock slope comprise two differ...

Abstract In this study, the effect of nailing angle on pull-out capacity nails in soil slopes was investigated using finite difference method with help FLAC 3D software. Initially, geometric model created at three different angles excavation slope (45°, 63°, and 80°). Considering Mohr–Coulomb behavioral applying physical parameters order to nail system, five rows angles, relative horizon, which...

Design earthquake ground motions for dynamic analyses are typically specified as outcrop motions, which may have to be modified for input at the base of a FLAC model. Often a ‘deconvolution’ analysis using a 1-D wave propagation code, such as the program SHAKE, is performed to obtain the appropriate input motion at depth. This seemingly simple analysis is often the subject of considerable confu...

Real-world applications routinely make authorization decisions based on dynamic computation. Rea-soning about dynamically computed authority is challenging. Integrity of the system might be compro-mised if attackers can improperly influence the authorizing computation. Confidentiality can also becompromised by authorization, since authorization decisions are often based on sensitive...

In many cases of heavy earthquakes, liquefaction has resulted in serious damages. Existing anisotropy in soil layers results  in some difficulties to realize the reason for these phenomena. Loose sand lenses buried in fine soils are one of the cases which may result in these problems and as a weak point during the earthquake can cause this phenomenon. In this paper, using FLAC 2D software, doub...

The models that were analyzed using FLAC version 4.0 (FLAC, 2000) are shown on Figure 5.1. The models have different soil types: loose silty sand with 20% fines content (Figures 5.1a and 5.1b), soft clay (Figure 5.1c), and silt (Figure 5.1d). Hence, the determination of the parameters is different for each model. The following sections discuss the determination of the parameters used in the ana...

The main goal of this research is to identify the system parameters of the dynamics of Rotor/Active Magnetic Bearing (Rotor/AMB) system employed in turbo molecular pumps (TMPs). The identification approach adopted in this work is based on experimental analysis and the application of Fuzzy Logic Adaptive ControlExtended Kalman Filter (FLAC-EKF). The estimation error for either system state or sy...