Fibrinolytic enzyme produced by Bacillus spp. are known to possess an unique property to degrade fibrin blood clots. Fibrinolytic enzyme such as nattokinase has commercial applications as a therapeutic agents and functional food formulation. In this study, we report an interesting characteristic feature of Bacillus subtilis BR21, a native isolate for its ability to produce multiple proteases th...

Thromboembolic events are potential complications of neurointerventional procedures. The mainstay of therapy for these complications is both supportive therapy and the use of fibrinolytic agents. In some cases, the occluding clot seems to be resistant to fibrinolytic or anti-platelet agents. We herein report our successful attempt at clot removal by using a microsnare to mechanically capture an...

To avoid the adverse effects of aprotinin (Apr) in autologous fibrin glue, we compared the inhibitory properties of four commercial anti-fibrinolytic agents (tranexamic acid (Tra), epsilon-aminocaproic acid (Ips), gabexate mesilate (Gab) and nafamostat mesilate (Naf)). The optimum conditions for the lysing of fibrin glue were an incubation temperature of 37 degrees C, and incubation medium cont...

BACKGROUND Fibrinolytic therapy is associated with frequent rethrombosis. There is evidence of both increased coagulation and platelet activation. METHODS AND RESULTS Platelet-rich plasma (PRP) or washed platelets were incubated with the fibrinolytic agents urokinase, recombinant tissue-type plasminogen activator (rt-PA), or plasmin at concentrations consistent with those in the plasma of pat...

abstract introduction the main function of the fibrinolytic system is to dissolve fibrin clots in circulation. this system is composed of inactive precursor plasminogen which can be converted into plasmin by the proteolytic enzymes like tissue-type plasminogen activator (tpa). fibrinolytic properties can be found in a variety of medicine plants and they could effectively prevent cardiovascular ...