Several species of the Myrcia genus have been used in folk medicine to treat diabetes. Therefore, aim this work was investigate inhibitory activity α-glucosidase and pancreatic lipase crude extract (EBF) ethyl acetate fraction (FFA) hatschbachii, as well identify isolated phenolic compounds evaluate antioxidant property preliminary vitro toxicity against Artemia salina. EBF (IC50: 3.21 μg/mL) F...

Analysis of the degree of overlap between functional magnetic resonance imaging-derived regions of interest (ROIs) has been used to assess the functional convergence and/or segregation of category-selective brain areas. An examination of the extant literature reveals no consistent usage for how such overlap is calculated, nor any systematic comparison between different methods. We argue that ho...

Overproduction of very low density lipoprotein (VLDL) is the major characteristic of subjects with familial combined hyperlipidemia (FCHL). As enhanced free fatty acid (FFA) flux to the liver may be one of the determinants of VLDL overproduction, we studied FFA changes and products of hepatic FFA metabolism in response to a 24-h oral fat loading test (50 g/m(2)) in 7 FCHL subjects and 7 matched...

Blue-veined cheeses in general undergo a pronounced lipolysis. The aim of this work was to determine the evolution free fatty acids (FFA) Valdeón cheese during ripening, comparing made from raw and pasteurized milk. effect season on FFA milk also studied. Cheeses with showed highest concentrations FFA, reaching values 23,081.9 mg 100 g?1 dry matter at end compared (7327.1 matter), both cases pr...

Previous studies of the uptake and release of free fatty acid (FFA) of various tissues (1, 2) have indicated that during the basal state there is usually a net release of FFA from the leg, but a more variable response in the forearm. This variability of forearm arteriovenous FFA differences has raised the issue of whether or not arteriovenous differences of total FFA alone provide an accurate i...

The model for export of fatty acids from plastids proposes that the acyl-ACP (acyl carrier protein) product of de novo fatty acid synthesis is hydrolyzed in the stroma by acyl-ACP thioesterases and the free fatty acid (FFA) released is then transferred to the outer envelope of the plastid where it is reactivated to acyl-CoA for utilization in cytosolic glycerolipid synthesis. Experiments were p...

Evidence, gained from human studies, is reviewed showing that elevation of plasma FFA levels produce peripheral and probably also hepatic insulin resistance in obese healthy and diabetic subjects. First, plasma FFA levels are elevated in most obese subjects. Second, physiological elevations of plasma FFA inhibit acutely as well as chronically insulin stimulated glucose uptake in a dose dependen...

BACKGROUND Circulating lipid levels and myocardial lipid content (MyLC) is increased in type 2 diabetes mellitus. This may cause a state of lipotoxicity that compromises left ventricular function and aggravate heart failure. We investigated the relationship among circulating lipid levels, MyLC, and cardiac function together with the acute cardiac effects of high as opposed to low circulating fr...

We determined the effect of flufenamic acid (FFA) and related derivatives on gap junction channel currents, applying the dual whole-cell patch-clamp technique to pairs of N2A neuroblastoma cells transfected with various connexins. FFA reduced gap junction channel currents in a reversible and concentration-dependent manner. Half-maximal concentrations for FFA-induced reduction of junctional cond...

Microbial free fatty acids (FFAs) have been proposed as a potential feedstock for renewable energy. The ability to directly convert carbon dioxide into FFAs makes cyanobacteria ideal hosts for renewable FFA production. Previous metabolic engineering efforts using the cyanobacterial hosts Synechocystis sp. PCC 6803 and Synechococcus elongatus PCC 7942 have demonstrated this direct conversion of ...