Background: Micronutrient deficiencies have been associated with significantly high reproductive risks, ranging from infertility to fetal structural defects and long-term diseases. Materials and Methods: In this review we focus on the reproductive risks related to some micronutrients during the periconceptional period, a critical step in determining fetal development and health due to the poten...

This article focuses on the range of fetal anomalies associated with varied alcohol ingestion during pregnancy. A means for identifying women at risk for having infants with alcohol related birth defects and the more severe fetal alcohol syndrome are discussed. Primary methods for preventing these lasting birth defects are described for practitioners.

OBJECTIVE To determine the need for fetal karyotyping in cases of an isolated single umbilical artery (SUA) identified during the second-trimester routine anomaly scan. METHODS All patients booked for antenatal care and delivery in our hospital are offered two ultrasound scans in pregnancy, one at 11-13 weeks' gestation as part of screening for chromosomal defects and another at 20-23 weeks f...

OBJECTIVE To analyse the prevalence of fetal and infant deaths due to birth defects in Korea and those trends according to maternal age. DESIGN Retrospective national cohort study SETTING: Korean Vital Statistics database of the Korean Statistical Information Service, between 2009 and 2015. PARTICIPANTS 2176 infant deaths and 4343 fetal deaths caused by birth defects, among 3 181 145 total ...

Objectives. To investigate the detection rate of major fetal heart defects in a low-risk population implementing routine use of color Doppler. Material and Methods. In a prospective observational study, all women undergoing fetal heart scanning (including 6781 routine examinations in the second trimester) during a three-year period were included. First a gray-scale scanning was performed includ...

The congenital heart defect is one of the major causes of neo retrospective study of all the patients with singleton pregnancies 2010-2012 was performed. The data collected included inform patients, the gestational age, the cardiac diagnosis, the extracar postnatal management and evolution. Out of 7,195 patients, (congenital heart defects). The mean gestational age was 34.12 recorded VSD (ventr...

OBJECTIVE To estimate whether parental thrombophilic defects after fetal death, either acquired or inherited, were more prevalent than in the normal population and to estimate associations between these thrombophilic defects and different fetal death causes. METHODS In a multicenter, prospective cohort study of 750 fetal deaths, we tested couples for antithrombin, protein C, total and free pr...

Objective To examine the association between increased nuchal translucency thickness and major cardiac defects in chromosomally normal fetuses. Setting Tertiary referral unit for fetal medicine and fetal

We describe a mouse model of fetal loss in factor V Leiden (FvL) mothers in which fetal loss is triggered when the maternal prothrombotic state coincides with fetal gene defects that reduce activation of the protein C anticoagulant pathway within the placenta. Fetal loss is caused by disruption of placental morphogenesis at the stage of labyrinth layer formation and occurs in the absence of ove...