The prenatal period is a critical time for neurodevelopment and is thus a period of vulnerability during which a range of exposures have been found to exert long-term changes on brain development and behavior with implications for physical and psychiatric health. During fetal life, neurons proliferate, migrate and form connections, providing the structure of the developing brain. Neurons reach ...

Introduction: The Serum/Glucose deprivation -induced cell death in cultured PC12 cells represents a useful in vitro model for the study of brain ischemia and neurodegenerative disorders. Nigella sativa L. has been known as a source of antioxidants. To elucidate the neuroprotective actions of N. sativa extract in vitro, we studied the effect of N. sativa extract on cultured PC12 cells under s...

Fetal MRI is emerging as an effective, non-invasive tool in prenatal diagnosis and pregnancy follow-up. However, there is a significant variability of the position and orientation of the fetus in the MR images. This makes these images more difficult to analyze and interpret compared to standard adult MR imaging, which standardized anatomical imaging aligned planes. We address this issue by auto...

background: diabetes is considered as one of the most common chronic disease. studies show that diabetes decreases the activity of antioxidant enzymes. the purpose of this study was to examine the effect of the alcoholic extract of juglans regia leave on brain antioxidant enzymes in streptozotocin-induced diabetic rats. materials and methods: in this study, adult male wistar rats (n=40, weight ...

Introduction This study presents the first direct investigation of fetal brain activity in utero using fMRI. Human fetal brain activity is usually studied indirectly by monitoring the changes in fetal heart rate and associated fetal movements, although recently fetal MEG has been attempted’. fMRI offers a safe and relatively robust method of monitoring fetal brain activity. This has major impli...

OBJECTIVES Nowadays much effort is being invested in order to diagnose the mechanisms involved in neural differentiation. By clarifying this, making desired neural cells in vitro and applying them into diverse neurological disorders suffered from neural cell malfunctions could be a feasible choice. Thus, the present study assessed the capability of fetal brain extract (FBE) to induce rat bone m...

background: the aim of this study was to apply the nested-pcr and bioassay methods in detection and genotyping of toxoplasma gondii infection in provided sheep aborted fetus samples from qazvin province of iran. methods : eighteen sheep aborted fetal samples were studied by nested-pcr-rflp, histopathologi­cal observation and microbiological assay. bioassay in mice was carried out by inoculating...

BACKGROUND Although catechins are known to be powerful antioxidants, no reports have shown their transport to fetal organs. We investigated the distribution of catechins in fetal rat organs after maternal exposure to green tea extract (GTE). METHODS GTE (550 mg/kg) or water was fed orally to pregnant dams at 15.5 days of gestation, the dams were sacrificed and fetal organs were dissected 0, 0...