A novel lachrymatory factor synthase (LFS) was isolated and purified from the roots of the Amazonian medicinal plant Petiveria alliacea. The enzyme is a heterotetrameric glycoprotein comprised of two alpha-subunits (68.8 kD each), one gamma-subunit (22.5 kD), and one delta-subunit (11.9 kD). The two alpha-subunits are glycosylated and connected by a disulfide bridge. The LFS has an isoelectric ...

INTRODUCTION Considering the prevalence of epilepsy and the failure of available treatments for many epileptic patients, finding more effective drugs in the treatment of epilepsy seems necessary. Oxidative stress has a special role in the pathogenesis of epileptic syndrome. Therefore, in the present study, we have examined the anti-epileptic and anti-oxidant properties of the Ferula Assa Foetid...

BACKGROUND The prevalence of Diabetes mellitus (DM) is escalating rapidly worldwide, and associated with micro- and macrovascular complications. Diabetic neuropathy (DN) is a common complication of DM, and has a few approved therapies with limited efficacy and several side-effects. Herbal medicine is used worldwide as an effective alternative-medicine. The present study aims to investigate the ...

BACKGROUND It was shown that plants derived agents are being used for treatment of cancer. In this study, crude ethanolic extract of Consolida orientalis L., Ferula assa-foetida L., Coronilla varia L., Orobanche orientalis G. Beck were screened in vitro for cytotoxic activity on Hela (Human cervical carcinoma) cell line. OBJECTIVES We performed the present study to evaluate the in vitro cytot...

This study was conducted at the animal production department, College of Agriculture Engineering Sciences , University Duhok, in order to investigate effect ration replacement with ferula on productive performance and some physiological parameters quail. Three hundred sixty day old quail birds were divided into four groups three replicates group (30 replicate, treated from age 7days till 42days...

The biodiversity of the Brazilian biomes inspires interest in research about biological activities molecules present flora. In this line, Petiveria alliacea a common plant species savanna Tocantins, reported treatment for snakebites, was studied to analyze phytochemical profile and evaluate activity on edema caused by Bothrops moojeni snake venom. A qualitative prospection gas chromatography as...

OBJECTIVE Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. MATERIALS AND METHODS Aerial parts, roots, ...

Anti-helmintic drug is an agent that destroys or causes the expulsion of parasitic intestinal worm. They may also be called vermifuges (stunning) or vermicides (killing). Asafoetida is the dried latex (gum oleoresin) exuded from the living underground rhizome or tap root of several species of Ferula (three of which grow in India), which is a perennial herb (1 to 1.5 m high). Asafoetida is exten...

Effect of hexane extract of Ferula jaeschkeana has been studied on corpora lutea of adult cyclic guinea-pigs. Administration of extract showed duration dependent luteolytic changes in the corpora lutea. Its administration for first three days from the onset of estrus caused significant decrease in the diameter of corpora lutea in the ovary at day 10 of cycle. Ovarian wet weight, proteins and gl...

The present study explores the hepatoprotective activity of various extracts of Ferula asafoetida, Momordica charantia Linn and Nardostachys jatamansi against experimental hepatotoxicity. Polyherbal suspensions were formulated using extracts showing significant activity and evaluated for both physicochemical and hepatoprotective activity in comparison with LIV-52 as standard. Petroleum ether (6...