Spikes of single cortical neurons can exert powerful effects even though most cortical synapses are too weak to fire postsynaptic neurons. A recent study combining single-cell stimulation with population imaging has visualized in vivo postsynaptic firing in genetically identified target cells. The results confirm predictions from in vitro work and might help to understand how the brain reads si...

Purified reovirus type 3 (strain Dearing) was treated with monoclonal anti-?l antibody conjugated to ferritin and examined in the electron microscope. Virion associated ferritin molecules corresponding to locations of the ?l protein were observed. Electron microsocpy of thin sections of these preparations revealed that ferritin conjugates were localized at the vertices of the viral icosahe...